@article{Ferrer:2015:10.1038/ncb3160,
author = {Ferrer, J and Cebola, I and Rodríguez-Seguí, SA and Cho, CH and Bessa, J and Rovira, M and Luengo, M and Chhatriwala, M and Berry, A and Ponsa-Cobas, J and Maestro, MA and Jennings, RE and Pasquali, L and Morán, I and Castro, N and Hanley, NA and Gomez-Skarmeta, JL and Vallier, L},
doi = {10.1038/ncb3160},
journal = {Nature Cell Biology},
pages = {615--626},
title = {TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors},
url = {http://dx.doi.org/10.1038/ncb3160},
volume = {17},
year = {2015}
}

Download

TY  - JOUR
AB  - The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas.
AU  - Ferrer,J
AU  - Cebola,I
AU  - Rodríguez-Seguí,SA
AU  - Cho,CH
AU  - Bessa,J
AU  - Rovira,M
AU  - Luengo,M
AU  - Chhatriwala,M
AU  - Berry,A
AU  - Ponsa-Cobas,J
AU  - Maestro,MA
AU  - Jennings,RE
AU  - Pasquali,L
AU  - Morán,I
AU  - Castro,N
AU  - Hanley,NA
AU  - Gomez-Skarmeta,JL
AU  - Vallier,L
DO  - 10.1038/ncb3160
EP  - 626
PY  - 2015///
SN  - 1476-4679
SP  - 615
TI  - TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
T2  - Nature Cell Biology
UR  - http://dx.doi.org/10.1038/ncb3160
UR  - https://www.nature.com/articles/ncb3160
VL  - 17
ER  - 

Download