@article{Woodbridge:2025:10.1371/journal.pone.0318150,
author = {Woodbridge, HR and Alexander, CM and Brett, SJ and Antcliffe, DB and Chan, EL and Gordon, AC},
doi = {10.1371/journal.pone.0318150},
journal = {PLOS ONE},
pages = {e0318150--e0318150},
title = {Investigating the safety of physical rehabilitation with critically ill patients receiving vasoactive drugs: An exploratory observational feasibility study},
url = {http://dx.doi.org/10.1371/journal.pone.0318150},
volume = {20},
year = {2025}
}

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TY  - JOUR
AB  - <jats:sec id="sec030"><jats:title>Background</jats:title><jats:p>Physical rehabilitation of critically ill patients may improve physical outcomes; however, the relative benefits and risks with patients requiring vasoactive drugs is currently unknown. A feasibility study is needed to inform the design of a future trial required to address this issue.</jats:p></jats:sec><jats:sec id="sec040"><jats:title>Methods</jats:title><jats:p>A two-phase exploratory observational feasibility study was carried out:</jats:p><jats:list list-type="order"><jats:list-item><jats:p>A retrospective study to clarify the current practice of rehabilitation with patients receiving vasoactive drugs to inform future trial interventions and design.</jats:p></jats:list-item><jats:list-item><jats:p>A prospective study exploring recruitment and outcome measurement. Intensive care patients receiving vasoactive drugs were recruited and asked about the acceptability of a future trial. The feasibility of using an adverse event tool was measured during rehabilitation. Patients were followed up after 60 days to describe the feasibility of measuring outcomes for a future trial.</jats:p></jats:list-item></jats:list></jats:sec><jats:sec id="sec032"><jats:title>Results</jats:title><jats:p>Retrospective study (n = 78): Twenty-one percent of patients took part in physical rehabilitation whilst receiving vasoactive drugs. Of 321 days with vasoactive drugs administered, physical rehabilitation occurred on 27 days (8%).</jats:p><jats:p>Prospective study (n = 40): Eighty-one percent of participants indicated acceptability of being recruited into a future trial (n = 37). Eighty-eight percent of clinicians found it acceptable to randomise patients into either early rehabilitation or standard care. The adverse ev
AU  - Woodbridge,HR
AU  - Alexander,CM
AU  - Brett,SJ
AU  - Antcliffe,DB
AU  - Chan,EL
AU  - Gordon,AC
DO  - 10.1371/journal.pone.0318150
EP  - 0318150
PY  - 2025///
SP  - 0318150
TI  - Investigating the safety of physical rehabilitation with critically ill patients receiving vasoactive drugs: An exploratory observational feasibility study
T2  - PLOS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0318150
UR  - https://doi.org/10.1371/journal.pone.0318150
VL  - 20
ER  - 

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