@article{Kennedy:2021:10.1097/j.pain.0000000000002277,
author = {Kennedy, DL and Vollert, J and Ridout, D and Alexander, CM and Rice, AS},
doi = {10.1097/j.pain.0000000000002277},
journal = {Pain},
pages = {2881--2893},
title = {The responsiveness of quantitative sensory testing-derived sensory phenotype to disease-modifying intervention in patients with entrapment neuropathy: a longitudinal study},
url = {http://dx.doi.org/10.1097/j.pain.0000000000002277},
volume = {162},
year = {2021}
}

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TY  - JOUR
AB  - ABSTRACT: The German Research Network on Neuropathic Pain (DFNS) quantitative sensory testing (QST) method for sensory phenotyping is used to stratify patients by mechanism associated sensory phenotype, theorised to be predictive of intervention efficacy. We hypothesised that change in pain and sensory dysfunction would relate to change in sensory phenotype. We investigated the responsiveness of sensory phenotype to surgery in patients with an entrapment neuropathy.With ethical approval and consent, this observational study recruited patients with neurophysiologically confirmed carpal tunnel syndrome. Symptom and pain severity parameters and DFNS QST were evaluated prior to and after carpal tunnel surgery. Surgical outcome was evaluated by patient-rated change. Symptom severity score of the Boston Carpal Tunnel Questionnaire and associated pain and paraesthesia subgroups were comparators for clinically relevant change.QST results (n=76) were compared to healthy controls (n=54). At 6 months post-surgery 92% participants reported a good surgical outcome and large decrease in pain and symptom severity (p<.001). Change in QST parameters occurred for thermal detection, thermal pain and mechanical detection thresholds with a moderate to large effect size. Change in mechanical pain measures were not statistically significant. Change occurred in sensory phenotype post-surgery (p<.001); sensory phenotype was associated with symptom subgroup (p=.03) and patient-rated surgical outcome (p =.02).QST derived sensory phenotype is sensitive to clinically important change. In an entrapment neuropathy model, sensory phenotype was associated with patient-reported symptoms and demonstrated statistically significant, clinically relevant change after disease modifying intervention. Sensory phenotype was independent of disease severity and may reflect underlying neuropathophysiology.
AU  - Kennedy,DL
AU  - Vollert,J
AU  - Ridout,D
AU  - Alexander,CM
AU  - Rice,AS
DO  - 10.1097/j.pain.0000000000002277
EP  - 2893
PY  - 2021///
SN  - 0304-3959
SP  - 2881
TI  - The responsiveness of quantitative sensory testing-derived sensory phenotype to disease-modifying intervention in patients with entrapment neuropathy: a longitudinal study
T2  - Pain
UR  - http://dx.doi.org/10.1097/j.pain.0000000000002277
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33769367
UR  - https://journals.lww.com/pain/Abstract/9000/The_responsiveness_of_quantitative_sensory.98083.aspx
VL  - 162
ER  - 

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