Immunology at the Crick covers a broad variety of topics ranging from basic molecular processes controlling immune cell activation to translational research into novel diagnostics and treatments for infectious and autoimmune diseases. The Immunology program is interdisciplinary, and can be divided into 4 major scientific areas that encompass various aspects of health and disease:

1. Immune homeostasis: including studies on the mechanisms underlying immune cell development and controlling immune cell function in tissues and organs
2. Autoimmune and inflammatory diseases: studying the processes leading to the dysregulation of immune responses in pathologies such as multiple sclerosis, psoriasis, colitis, sepsis and allergies.
3. Cancer immunology: analysing the role of immune cells in the development and progression of tumours.
4. Host-pathogen interactions: including studies on the biology of pathogens as well as infectious diseases caused by bacteria, viruses or parasites in diseases such as malaria, tuberculosis, influenza or COVID.