Publications 2022

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A.
Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J, Schnoor M, Voehringer D, Roers A, Nourshargh S, Voisin MB.
Nat Commun, 13(1):7029, 17 Nov 2022 | PMID: 36396641 | PMCID: PMC9672103 | DOI: 10.1038/s41467-022-34695-7

Identification of an increased lifetime risk of major adverse cardiovascular events in UK Biobank participants with scoliosis
Santofimio VQ, Clement A, O’Regan DP, Ware JS, McGurk KA.
medRxiv, 22 Nov 2022 | PPR: PPR574259 | DOI: 10.1101/2022.11.21.22282578

PAT-CNN: Automatic Segmentation and Quantification of Pericardial Adipose Tissue from T2-Weighted Cardiac Magnetic Resonance Images
Z Li, C Petri, J Howard, G Cole, M Varela.
arXiv preprint arXiv:2211.04995. Nov 2022. https://doi.org/10.48550/arXiv.2211.04995

The electrophysiological-anatomical substrate of the pulmonary vein sleeves promotes the synchronisation of spontaneous focal excitations and the generation of unidirectional.
MA Colman, M Varela, J Hancox, O Aslanidi
ACTA PHYSIOLOGICA 236, 190-191 | https://onlinelibrary.wiley.com/doi/epdf/10.1111/apha.13875

An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Ainscough AJ, Smith TJ, Haensel M, Rhodes CJ, Fellows A, Whitwell HJ, Vasilaki E, Gray K, Freeman A, Howard LS, Wharton J, Dunmore B, Upton PD, Wilkins MR, Edel JB, Wojciak-Stothard B.
Commun Biol, 5(1):1192, Nov 2022| PMID: 36344664 | PMCID: PMC9640600 | DOI: 10.1038/s42003-022-04169-z

Morphological, functional, and biomechanical progression of LV remodelling in a porcine model of HFpEF.
Zheng Y, Chan WX, Charles CJ, Richards AM, Lee LC, Leo HL, Yap CH. 
J Biomech, 144:111348, 12 Oct 2022 | PMID: 36265421 | DOI: 10.1016/j.jbiomech.2022.111348

Environmental and genetic predictors of human cardiovascular ageing
Shah M, Inácio MHdA, Lu C, Schiratti P, Zheng SL, Clement A, Bai W, King AP, Ware JS, Wilkins MR, Mielke J, Elci E, Kryukov I, McGurk KA, Bender C, Freitag DF, O’Regan DP. 
medRxiv, 04 Oct 2022 | PPR: PPR553765 | DOI: 10.1101/2022.10.03.22280042

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.
Broto M, Kaminski MM, Adrianus C, Kim N, Greensmith R, Dissanayake-Perera S, Schubert AJ, Tan X, Kim H, Dighe AS, Collins JJ, Stevens MM. 
Nat Nanotechnol, 17(10):1120-1126, 04 Aug 2022 | PMID: 35927321 | DOI: 10.1038/s41565-022-01179-0

Determining the genetic contribution in patients with non-syndromic ascending thoracic aortic aneurysms: Correlation with findings from computational pathology.
Salmasi MY, Morris-Rosendahl D, Jarral OA, Rosendahl U, Asimakopoulos G, Raja S, Aragon-Martin JA, Child A, Pepper J, Oo A, Athanasiou T, London Aortic Mechanobiology Working Group.
Int J Cardiol, 366:1-9, 10 Jul 2022 | PMID: 35830949 | DOI: 10.1016/j.ijcard.2022.07.010

Dilated cardiomyopathy - details make the difference.
McGurk KA, Halliday BP
Eur J Heart Fail, 24(7):1197-1199, 05 Jul 2022 | PMID: 35717623 | DOI: 10.1002/ejhf.2586

Effect of taurine administration on symptoms, severity, or clinical outcome of dilated cardiomyopathy and heart failure in humans: a systematic review.
McGurk KA, Kasapi M, Ware JS
Wellcome Open Res, 07 Jul 2022 | PPR: PPR515431 | PMID: 35855073 | PMCID: PMC9257265 | DOI: 10.12688/wellcomeopenres.17505.3

Deep Learning methods for automatic evaluation of delayed enhancement-MRI. The results of the EMIDEC challenge
A Lalande, Z Chen, T Pommier, T Decourselle, A Qayyum, M Salomon, D Ginhac, Y Skandarani, A Boucher, K Brahim, M deBruijne, R Camarasa, T Correia, X Feng, K Girum, A Hennemuth, M Huellebrand, R Hussain, M Ivantsits, J Ma, C Meyer, R Sharma, J Shi, N Tsekos, M Varela.
Medical Image Analysis 79, 102428. July 2022. | PMID: 35500498 | DOI: 10.1016/j.media.2022.102428

The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med.  
DiStefano MT, Goehringer S, Babb L, Alkuraya FS, Amberger J, Amin M, Austin-Tse C, Balzotti M, Berg JS, Birney E, Bocchini C, Bruford EA, Coffey AJ, Collins H, Cunningham F, Daugherty LC, Einhorn Y, Firth HV, Fitzpatrick DR, Foulger RE, Goldstein J, Hamosh A, Hurles MR, Leigh SE, Leong IUS, Maddirevula S, Martin CL, McDonagh EM, Olry A, Puzriakova A, Radtke K, Ramos EM, Rath A, Riggs ER, Roberts AM, Rodwell C, Snow C, Stark Z, Tahiliani J, Tweedie S, Ware JS, Weller P, Williams E, Wright CF, Yates TM
Rehm HL. 2022 May 4: S1098-3600(22)00746-8 | Epub ahead of print | PMID: 35507016 | PMCID: PMC7613247 | DOI: 10.1016/j.gim.2022.04.017

Risk prediction for thoracic aortic dissection: Is it time to go with the flow?
Salmasi MY, Pirola S, Asimakopoulos G, Nienaber C, Athanasiou T, London Aortic Mechanobiology Working Group.
J Thorac Cardiovasc Surg, S0022-5223(22)00605-5, 16 May 2022 | PMID: 35672182 | DOI: 10.1016/j.jtcvs.2022.05.016

Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension.
Rhodes CJ, Wharton J, Swietlik EM, Harbaum L, Girerd B, Coghlan JG, Lordan J, Church C, Pepke-Zaba J, Toshner M, Wort SJ, Kiely DG, Condliffe R, Lawrie A, Gräf S, Montani D, Boucly A, Sitbon O, Humbert M, [...] Wilkins MR. 
Am J Respir Crit Care Med, 205(9):1102-1111, 01 May 2022| PMID: 35081018 | PMCID: PMC9851485 | DOI: 10.1164/rccm.202105-1118OC

Prognostic significance of ventricular arrhythmias in 13444 patients with acute coronary syndrome: a retrospective cohort study based on routine clinical data (NIHR Health Informatics Collaborative VA-ACS Study). JAHA (in press).
Sau A, Kaura A, Ahmed A, Patel K, Li X, Mulla A, Glampson B, Panoulas V, Davies J, Woods K, Gautama S, Shah AD, Elliott P, Hemingway H, Williams B, Asselbergs FW, Melikian N, Peters NS, Shah AM, Perera D, Kharbanda R, Patel RS, Channon KM, Mayet J, Ng FS. 
J Am Heart Assoc. March 2022. PMID: 35258317 | PMCID: PMC9075290 |DOI: 10.1161/JAHA.121.024260

Evaluation of Computational Methodologies for Accurate Prediction of Wall Shear Stress and Turbulence Parameters in a Patient-Specific Aorta.
Manchester EL, Pirola S, Salmasi MY, O'Regan DP, Athanasiou T, Xu XY. 
Front Bioeng Biotechnol, 10:836611, 24 Mar 2022| PMID: 35402418 | PMCID: PMC8987126 |DOI: 10.3389/fbioe.2022.836611

The mortality risk prediction of mildly elevated high-sensitivity C-reactive protein beyond troponin in 102337 patients with suspected acute coronary syndrome (NIHR Health Informatics Collaborative CRP-RISK Study): A retrospective cohort study. PLOS Medicine (in press).
Kaura A, Hartley A, Panoulas V, Glampson B, Davies J, Mulla A, Woods K, Omigie J, Shah AD, Channon KM, Weber JN, Thursz MR, Elliott P, Hemingway H, Williams B, Asselbergs FW, O'Sullivan M, Lord GM, Trickey A, Sterne JAC, Haskard D, Melikian N, Francis DP, Koenig W, Shah AM, Kharbanda R, Perera D, Patel RS, Mayet J, Khamis R. 
Plos Med. Feb 2022 | PMID: 35192610| PMCID: PMC8863282 | DOI: 10.1371/journal.pmed.1003911

LA-Net: A Multi-Task Deep Network for the Segmentation of the Left Atrium.
Uslu F, Varela M, Boniface G, Mahenthran T, Chubb H, Bharath AA
IEEE Trans Med Imaging, 41(2):456-464, 02 Feb 2022 | PMID: 34606450 | DOI: 10.1109/TMI.2021.3117495

EP-PINNs: Cardiac electrophysiology characterisation using physics-informed neural networks
C Herrero Martin, A Oved, RA Chowdhury, E Ullmann, NS Peters, Anil A Bareth, M Varela. 
Frontiers in cardiovascular medicine, 2179. February 2022 | PMID: 35187101 | PMCID: PMC8850959 | DOI: 10.3389/fcvm.2021.768419

Publications 2021

Correspondence on “ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)” by Miller et al.
McGurk, et al.,
Genet. Med. Nov 2021 | https://doi.org/10.1016/j.gim.2021.10.020

Sharpening focus through wider collaboration: evolving heterogeneity in the bi-directional relationship between cardiovascular disease and COVID-19.
Kaura A, Mayet J, Manisty C
Eur Heart J, 04 Nov 2021| PMID: 34734637 | PMCID: PMC8689893 | DOI: 10.1093/eurheartj/ehab622

Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses.
Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration
Lancet Diabetes Endocrinol, 9(12):837-846, 28 Oct 2021| PMID: 34717822 | PMCID: PMC8600124 | DOI: 10.1016/S2213-8587(21)00263-1

Genetically Predicted Type 2 Diabetes Mellitus Liability, Glycated Hemoglobin and Cardiovascular Diseases: A Wide-Angled Mendelian Randomization Study.
Liu B, Mason AM, Sun L, Di Angelantonio E, Gill D, Burgess S
Genes (Basel), 12(10), 19 Oct 2021| PMID: 34681038 | PMCID: PMC8536164 | DOI: 10.3390/genes12101644

High Wall Shear Stress can Predict Wall Degradation in Ascending Aortic Aneurysms: An Integrated Biomechanics Study.
Salmasi MY, Pirola S, Sasidharan S, Fisichella SM, Redaelli A, Jarral OA, O'Regan DP, Oo AY, Moore JE, Xu XY, Athanasiou T
Front Bioeng Biotechnol, 9:750656, 18 Oct 2021| PMID: 34733832 | PMCID: PMC8558434 | DOI: 10.3389/fbioe.2021.750656

Life expectancy and risk of death in 6791 communities in England from 2002 to 2019: high-resolution spatiotemporal analysis of civil registration data.
Rashid T, Bennett JE, Paciorek CJ, Doyle Y, Pearson-Stuttard J, Flaxman S, Fecht D, Toledano MB, Li G, Daby HI, Johnson E, Davies B, Ezzati M
Lancet Public Health, 6(11):e805-e816, 13 Oct 2021| PMID: 34653419 | PMCID: PMC8554392 | DOI: 10.1016/S2468-2667(21)00205-X

LA-Net: A Multi-task Deep Network For The Segmentation of The Left Atrium.
Uslu F, Varela M, Boniface G, Mahenthran T, Chubb H, Bharath AA
IEEE Trans Med Imaging, PP, 04 Oct 2021| PMID: 34606450 | DOI: 10.1109/TMI.2021.3117495

Predictive symptoms for COVID-19 in the community: REACT-1 study of over 1 million people.
Elliott J, Whitaker M, Bodinier B, Eales O, Riley S, Ward H, Cooke G, Darzi A, Chadeau-Hyam M, Elliott P
PLoS Med, 18(9):e1003777, 28 Sep 2021| PMID: 34582457 | PMCID: PMC8478234 | DOI: 10.1371/journal.pmed.1003777 /Free to read & use

Phenotypic expression and outcomes in individuals with rare genetic variants of hypertrophic cardiomyopathy.
de Marvao, et al., Sept 2021, JACC. | PMID: 34503678 | PMCID: PMC8434420 | DOI: 10.1016/j.jacc.2021.07.017

Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death.
Walsh R, Adler A, Amin AS, Abiusi E, Care M, Bikker H, Amenta S, Feilotter H, Nannenberg EA, Mazzarotto F, Trevisan V, Garcia J, Hershberger RE, Perez MV, Sturm AC, Ware JS, Zareba W, Novelli V, Wilde AAM, Gollob MH
Eur Heart J, 24 Sep 2021| PMID: 34557911 | PMCID: PMC9009401 | DOI: 10.1093/eurheartj/ehab687

Full cardiac cycle asynchronous temporal compounding of 3D echocardiography images.
Chan WX, Zheng Y, Wiputra H, Leo HL, Yap CH
Med Image Anal, 74:102229, 16 Sep 2021| PMID: 34571337 | DOI: 10.1016/j.media.2021.102229

Leveraging genetic data to investigate the effects of interleukin-6 receptor signalling on levels of 40 circulating cytokines.
Rahman RP, McEwan L, Ryan DK, Gill D
Br J Clin Pharmacol, 10 Sep 2021| PMID: 34506050 | DOI: 10.1111/bcp.15079

Mental Health as a Mediator of the Association Between Educational Inequality and Cardiovascular Disease: A Mendelian Randomization Study.
Jones DP, Wootton RE, Gill D, Carter AR, Gunnell D, Munafò MR, Sallis HM
J Am Heart Assoc, 10(17):e019340, 02 Sep 2021| PMID: 34472355 | PMCID: PMC8649303 | DOI: 10.1161/JAHA.120.019340

Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy.
de Marvao A, McGurk KA, Zheng SL, Thanaj M, Bai W, Duan J, Biffi C, Mazzarotto F, Statton B, Dawes TJW, Savioli N, Halliday BP, Xu X, Buchan RJ, Baksi AJ, Quinlan M, Tokarczuk P, Tayal U, Francis C, [...] O'Regan DP
J Am Coll Cardiol, 78(11):1097-1110, 01 Sep 2021| PMID: 34503678 | PMCID: PMC8434420 | DOI: 10.1016/j.jacc.2021.07.017 /Free to read & use

Learning a Model-Driven Variational Network for Deformable Image Registration.
Jia X, Thorley A, Chen W, Qiu H, Shen L, Styles IB, Chang HJ, Leonardis A, De Marvao A, O'Regan DP, Rueckert D, Duan J
IEEE Trans Med Imaging, PP, 30 Aug 2021| PMID: 34460369 | DOI: 10.1109/TMI.2021.3108881

Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank.
Higgins H, Mason AM, Larsson SC, Gill D, Langenberg C, Burgess S
J Am Heart Assoc, 10(17):e021098, 28 Aug 2021| PMID: 34459231 | PMCID: PMC8649307 | DOI: 10.1161/JAHA.121.021098

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. 
NCD Risk Factor Collaboration (NCD-RisC). 
Lancet, 398(10304):957-980, 24 Aug 2021| PMID: 34450083 | PMCID: PMC8446938 | DOI: 10.1016/S0140-6736(21)01330-1 

Left ventricular activation time and pattern are preserved with both selective and nonselective His bundle pacing.
Arnold AD, Shun-Shin MJ, Ali N, Keene D, Howard JP, Chow JJ, Qureshi NA, Koa-Wing M, Tanner M, Lefroy DC, Linton NWF, Ng FS, Lim PB, Peters NS, Kanagaratnam P, Francis DP, Whinnett ZI
Heart Rhythm O2, 2(5):439-445, 11 Aug 2021| PMID: 34667958 | PMCID: PMC8505200 | DOI: 10.1016/j.hroo.2021.08.001

Cross-sectional analysis of educational inequalities in primary prevention statin use in UK Biobank.
Carter AR, Gill D, Davey Smith G, Taylor AE, Davies NM, Howe LD
Heart, 27 Jul 2021| PMID: 34315717 | PMCID: PMC8921562 | DOI: 10.1136/heartjnl-2021-319238

Clinical impact of re-evaluating genes and variants implicated in dilated cardiomyopathy.
Stroeks SLVM, Hellebrekers DMEI, Claes GRF, Tayal U, Krapels IPC, Vanhoutte EK, van den Wijngaard A, Henkens MTHM, Ware JS, Heymans SRB, Brunner HG, Verdonschot JAJ
Genet Med, 23(11):2186-2193, 30 Jun 2021| PMID: 34194005 | DOI: 10.1038/s41436-021-01255-1

Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure.
Daghlas I, Karhunen V, Ray D, Zuber V, Burgess S, Tsao PS, Lynch JA, Lee KM, Voight BF, Chang KM, Baker EH, Damrauer SM, Howson JMM, Vujkovic M, Gill D
J Am Heart Assoc, 10(13):e020331, 29 Jun 2021| PMID: 34184541 | PMCID: PMC8403330 | DOI: 10.1161/JAHA.120.020331

Community factors and excess mortality in first wave of the COVID-19 pandemic in England.
Davies B, Parkes BL, Bennett J, Fecht D, Blangiardo M, Ezzati M, Elliott P
Nat Commun, 12(1):3755, 18 Jun 2021| PMID: 34145260 | PMCID: PMC8213785 | DOI: 10.1038/s41467-021-23935-x

Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM
Circulation, 144(5):353-364, 18 Jun 2021| PMID: 34139859 | PMCID: PMC8323712 | DOI: 10.1161/CIRCULATIONAHA.121.053797

Causal Effect of Adiposity Measures on Blood Pressure Traits in 2 Urban Swedish Cohorts: A Mendelian Randomization Study.
Giontella A, Lotta LA, Overton JD, Baras A, Regeneron Genetics Center, Minuz P, Melander O, Gill D, Fava C
J Am Heart Assoc, 10(13):e020405, 14 Jun 2021| PMID: 34120448 | PMCID: PMC8403279 | DOI: 10.1161/JAHA.120.020405

Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis.
Fatumo S, Karhunen V, Chikowore T, Sounkou T, Udosen B, Ezenwa C, Nakabuye M, Soremekun O, Daghlas I, Ryan DK, Taylor A, Mason AM, Damrauer SM, Vujkovic M, Keene KL, Fornage M, Järvelin MR, Burgess S, Gill D
Stroke, 52(8):2680-2684, 03 Jun 2021| PMID: 34078102 | PMCID: PMC8312569 | DOI: 10.1161/STROKEAHA.121.034747

Alcohol consumption in the general population is associated with structural changes in multiple organ systems.
Evangelou E, Suzuki H, Bai W, Pazoki R, Gao H, Matthews PM, Elliott P
Elife, 10, 01 Jun 2021| PMID: 34059199 | PMCID: PMC8192119 | DOI: 10.7554/eLife.65325

Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis.
Gill D, Zuber V, Dawson J, Pearson-Stuttard J, Carter AR, Sanderson E, Karhunen V, Levin MG, Wootton RE, Klarin D, Tsao PS, Tsilidis KK, Damrauer SM, Burgess S, Elliott P
Int J Obes (Lond), 45(7):1428-1438, 17 May 2021| PMID: 34002035 | PMCID: PMC8236409 | DOI: 10.1038/s41366-021-00807-4

Prevalence of antibody positivity to SARS-CoV-2 following the first peak of infection in England: Serial cross-sectional studies of 365,000 adults.
Ward H, Cooke GS, Atchison C, Whitaker M, Elliott J, Moshe M, Brown JC, Flower B, Daunt A, Ainslie K, Ashby D, Donnelly CA, Riley S, Darzi A, Barclay W, Elliott P
Lancet Reg Health Eur, 4:100098, 02 May 2021| PMID: 33969335 | PMCID: PMC8088780 | DOI: 10.1016/j.lanepe.2021.100098

Annotating high-impact 5'untranslated region variants with the UTRannotator.
Zhang X, Wakeling M, Ware J, Whiffin N
Bioinformatics, 37(8):1171-1173, 01 May 2021| PMID: 32926138 | PMCID: PMC8150139 | DOI: 10.1093/bioinformatics/btaa783

Usability and Acceptability of Home-based Self-testing for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies for Population Surveillance.
Atchison C, Pristerà P, Cooper E, Papageorgiou V, Redd R, Piggin M, Flower B, Fontana G, Satkunarajah S, Ashrafian H, Lawrence-Jones A, Naar L, Chigwende J, Gibbard S, Riley S, Darzi A, Elliott P, Ashby D, Barclay W, [...] Ward H
Clin Infect Dis, 72(9):e384-e393, 01 May 2021| PMID: 32785665 | PMCID: PMC7454392 | DOI: 10.1093/cid/ciaa1178

Resurgence of SARS-CoV-2: Detection by community viral surveillance.
Riley S, Ainslie KEC, Eales O, Walters CE, Wang H, Atchison C, Fronterre C, Diggle PJ, Ashby D, Donnelly CA, Cooke G, Barclay W, Ward H, Darzi A, Elliott P
Science, 372(6545):990-995, 23 Apr 2021| PMID: 33893241 | PMCID: PMC8158959 | DOI: 10.1126/science.abf0874

Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study.
Yuan S, Burgess S, Laffan M, Mason AM, Dichgans M, Gill D, Larsson SC
J Am Heart Assoc, 10(8):e019644, 09 Apr 2021| PMID: 33834859 | PMCID: PMC8174173 | DOI: 10.1161/JAHA.120.019644

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses. 
Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D 
Hypertension, 77(6):2004-2013, 05 Apr 2021| PMID: 33813844 | PMCID: PMC8115430 | DOI: 10.1161/HYPERTENSIONAHA.120.16534

Plasma metabolomics exhibit response to therapy in chronic thromboembolic pulmonary hypertension.
Swietlik EM, Ghataorhe P, Zalewska KI, Wharton J, Howard LS, Taboada D, Cannon JE, UK National Cohort Study of PAH, Morrell NW, Wilkins MR, Toshner M, Pepke-Zaba J, Rhodes CJ
Eur Respir J, 57(4), 01 Apr 2021 | PMID: 33060150 | PMCID: PMC8012591 | DOI: 10.1183/13993003.03201-2020

Genetically proxied growth-differentiation factor 15 levels and body mass index.
Karhunen V, Larsson SC, Gill D
Br J Clin Pharmacol, 87(10):4036-4039, 19 Mar 2021| PMID: 33686698 | DOI: 10.1111/bcp.14808

COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors.
Elliott J, Bodinier B, Whitaker M, Delpierre C, Vermeulen R, Tzoulaki I, Elliott P, Chadeau-Hyam M
Eur J Epidemiol, 36(3):299-309, 15 Feb 2021| PMID: 33587202 | PMCID: PMC7882869 | DOI: 10.1007/s10654-021-00722-y

Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing.
Tijsen AJ, Cócera Ortega L, Reckman YJ, Zhang X, van der Made I, Aufiero S, Li J, Kamps SC, van den Bout A, Devalla HD, van Spaendonck-Zwarts KY, Engelhardt S, Gepstein L, Ware JS, Pinto YM
Circulation, 143(15):1502-1512, 15 Feb 2021| PMID: 33583186 | PMCID: PMC8032209 | DOI: 10.1161/CIRCULATIONAHA.120.050455

SARS-CoV-2 antibody prevalence in England following the first peak of the pandemic.
Ward H, Atchison C, Whitaker M, Ainslie KEC, Elliott J, Okell L, Redd R, Ashby D, Donnelly CA, Barclay W, Darzi A, Cooke G, Riley S, Elliott P
Nat Commun, 12(1):905, 10 Feb 2021| PMID: 33568663 | PMCID: PMC7876103 | DOI: 10.1038/s41467-021-21237-w

Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies.
Mazzarotto F, Hawley MH, Beltrami M, Beekman L, de Marvao A, McGurk KA, Statton B, Boschi B, Girolami F, Roberts AM, Lodder EM, Allouba M, Romeih S, Aguib Y, Baksi AJ, Pantazis A, Prasad SK, Cerbai E, Yacoub MH, [...] Walsh R
Genet Med, 23(5):856-864, 26 Jan 2021| PMID: 33500567 | PMCID: PMC8105165 | DOI: 10.1038/s41436-020-01049-x

Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
Burgess S, Malik R, Liu B, Mason AM, Georgakis MK, Dichgans M, Gill D
Diabetologia, 64(4):845-849, 26 Jan 2021| PMID: 33495845 | PMCID: PMC7940279 | DOI: 10.1007/s00125-020-05377-0

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.
Tadros R, Francis C, Xu X, Vermeer AMC, Harper AR, Huurman R, Kelu Bisabu K, Walsh R, Hoorntje ET, Te Rijdt WP, Buchan RJ, van Velzen HG, van Slegtenhorst MA, Vermeulen JM, Offerhaus JA, Bai W, de Marvao A, Lahrouchi N, Beekman L, [...] Bezzina CR
Nat Genet, 53(2):128-134, 25 Jan 2021| PMID: 33495596 | PMCID: PMC7611259 | DOI: 10.1038/s41588-020-00762-2

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.
Gill D, Karhunen V, Malik R, Dichgans M, Sofat N
Osteoarthritis Cartilage, 29(3):365-371, 07 Jan 2021| PMID: 33422704 | PMCID: PMC7955282 | DOI: 10.1016/j.joca.2020.12.015

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells.
McCracken IR, Saginc G, He L, Huseynov A, Daniels A, Fletcher S, Peghaire C, Kalna V, Andaloussi-Mäe M, Muhl L, Craig NM, Griffiths SJ, Haas JG, Tait-Burkard C, Lendahl U, Birdsey GM, Betsholtz C, Noseda M, Baker AH, Randi AM
Circulation, 143(8):865-868, 06 Jan 2021| PMID: 33405941 | PMCID: PMC7899720 | DOI: 10.1161/CIRCULATIONAHA.120.052824

Genetically Predicted Blood Pressure and Risk of Atrial Fibrillation.
Hyman MC, Levin MG, Gill D, Walker VM, Georgakis MK, Davies NM, Marchlinski FE, Damrauer SM
Hypertension, 77(2):376-382, 04 Jan 2021| PMID: 33390040 | PMCID: PMC7803440 | DOI: 10.1161/HYPERTENSIONAHA.120.16191

The genetic architecture of left ventricular non-compaction reveals both substantial overlap with other cardiomyopathies and a distinct aetiology in a subset of cases.
Mazzarotto, et al.,
Jan 2021, Genet. Med.doi: https://doi.org/10.1038/s41436-020-01049-x

 

Publications 2020

A Mendelian randomization of γ' and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke.
Maners J, Gill D, Pankratz N, Laffan MA, Wolberg AS, de Maat MPM, Ligthart S, Tang W, Ward-Caviness CK, Fornage M, Debette S, Dichgans M, McKnight B, Boerwinkle E, CHARGE Inflammation Working Group, INVENT Consortium, MEGASTROKE consortium of the International Stroke Genetics Consortium (ISGC), Smith NL, Morrison AC, [...] de Vries PS
Blood, 136(26):3062-3069, 01 Dec 2020| PMID: 33367543 | PMCID: PMC7770565 | DOI: 10.1182/blood.2019004781

Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study.
Chadeau-Hyam M, Bodinier B, Vermeulen R, Karimi M, Zuber V, Castagné R, Elliott J, Muller D, Petrovic D, Whitaker M, Stringhini S, Tzoulaki I, Kivimäki M, Vineis P, Elliott P, Kelly-Irving M, Delpierre C
EClinicalMedicine, 29-30:100658, 19 Nov 2020| PMID: 33437953 | PMCID: PMC7788440 | DOI: 10.1016/j.eclinm.2020.100658

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.
Gill D, Arvanitis M, Carter P, Hernández Cordero AI, Jo B, Karhunen V, Larsson SC, Li X, Lockhart SM, Mason A, Pashos E, Saha A, Tan VY, Zuber V, Bossé Y, Fahle S, Hao K, Jiang T, Joubert P, [...] Burgess S
R Soc Open Sci, 7(11):200958, 18 Nov 2020| PMID: 33391794 | PMCID: PMC7735342 | DOI: 10.1098/rsos.200958

N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects
Wood FA, Howard JP, Finegold JA, Nowbar AN, Thompson DM, Arnold AD, Rajkumar CA, Connolly S, Cegla J, Stride C, Sever P, Norton C, Thom SAM, Shun-Shin MJ, Francis DP.
N Engl J Med. 2020 Nov 15. doi: 10.1056/NEJMc2031173

Blood Pressure Modification and Life Expectancy in a General Population: Mendelian Randomization Analysis.
Daghlas I, Gill D
Circ Genom Precis Med, 13(6):e003143, 14 Nov 2020| PMID: 33191764 | DOI: 10.1161/CIRCGEN.120.003143

Electrocardiographic predictors of successful resynchronization of left bundle branch block by His bundle pacing.
Arnold AD, Shun-Shin MJ, Keene D, Howard JP, Chow JJ, Lim E, Lampridou S, Miyazawa AA, Muthumala A, Tanner M, Qureshi NA, Lefroy DC, Koa-Wing M, Linton NWF, Boon Lim P, Peters NS, Kanagaratnam P, Auricchio A, Francis DP, Whinnett ZI
J Cardiovasc Electrophysiol, Feb 2021 | PMID: 33345379 | PMCID: PMC8607473 | DOI: 10.1111/jce.14845

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension.
Ulrich A, Otero-Núñez P, Wharton J, Swietlik EM, Gräf S, Morrell NW, Wang D, Lawrie A, Wilkins MR, Prokopenko I, Rhodes CJ, Consortium OBOTNBD, Consortium UPCS
Genes (Basel), 11(11), 22 Oct 2020| PMID: 33105808 | PMCID: PMC7690609 | DOI: 10.3390/genes11111247

Disease-specific variant pathogenicity prediction significantly improves variant interpretation in inherited cardiac conditions.
Zhang X, Walsh R, Whiffin N, Buchan R, Midwinter W, Wilk A, Govind R, Li N, Ahmad M, Mazzarotto F, Roberts A, Theotokis PI, Mazaika E, Allouba M, de Marvao A, Pua CJ, Day SM, Ashley E, Colan SD, [...] Ware JS
Genet Med, 23(1):69-79, 13 Oct 2020| PMID: 33046849 | PMCID: PMC7790749 | DOI: 10.1038/s41436-020-00972-3

A survey of pathways for mechano-electric coupling in the atria.
Marta Varela, Roy A, Lee J
Prog Biophys Mol Biol, 159:136-145, 11 Oct 2020| PMID: 33053408 | PMCID: PMC7848589 | DOI: 10.1016/j.pbiomolbio.2020.09.011

A population-based phenome-wide association study of cardiac and aortic structure and function.
Bai W, Suzuki H, Huang J, Francis C, Wang S, Tarroni G, Guitton F, Aung N, Fung K, Petersen SE, Piechnik SK, Neubauer S, Evangelou E, Dehghan A, O'Regan DP, Wilkins MR, Guo Y, Matthews PM, Rueckert D
Nat Med, 26(10):1654-1662, 24 Aug 2020| PMID: 32839619 | PMCID: PMC7613250 | DOI: 10.1038/s41591-020-1009-y

Genetic and functional insights into the fractal structure of the heart.
Meyer HV, Dawes TJW, Serrani M, Bai W, Tokarczuk P, Cai J, de Marvao A, Henry A, Lumbers RT, Gierten J, Thumberger T, Wittbrodt J, Ware JS, Rueckert D, Matthews PM, Prasad SK, Costantino ML, Cook SA, Birney E, O'Regan DP
Nature, 584(7822):589-594, 19 Aug 2020| PMID: 32814899 | PMCID: PMC7116759 | DOI: 10.1038/s41586-020-2635-8

Interpretable XGBoost Based Classification of 12-lead ECGs Applying Information Theory Measures From Neuroscience.
Rajpal H, Sas M, Lockwood C, Joakim R, Peters NS, Falkenberg M
Comput Cardiol (2010), 47, 14 Aug 2020| PMID: 33763495 | PMCID: PMC7610399 | DOI: 10.22489/CinC.2020.185

Use of a Genetic Variant Related to Circulating FXa (Activated Factor X) Levels to Proxy the Effect of FXa Inhibition on Cardiovascular Outcomes.
Gill D, Burgess S
Circ Genom Precis Med, 13(5):551-553, 13 Aug 2020| PMID: 33079601 | PMCID: PMC7676614 | DOI: 10.1161/CIRCGEN.120.003061

Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data.
Kaura A, Sterne JAC, Trickey A, Abbott S, Mulla A, Glampson B, Panoulas V, Davies J, Woods K, Omigie J, Shah AD, Channon KM, Weber JN, Thursz MR, Elliott P, Hemingway H, Williams B, Asselbergs FW, O'Sullivan M, [...] Mayet J
Lancet, 396(10251):623-634, 01 Aug 2020| PMID: 32861307 | PMCID: PMC7456783 | DOI: 10.1016/S0140-6736(20)30930-2

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome.
Rhodes CJ, Otero-Núñez P, Wharton J, Swietlik EM, Kariotis S, Harbaum L, Dunning MJ, Elinoff JM, Errington N, Thompson AAR, Iremonger J, Coghlan JG, Corris PA, Howard LS, Kiely DG, Church C, Pepke-Zaba J, Toshner M, Wort SJ, [...] Wilkins MR
Am J Respir Crit Care Med, 202(4):586-594, 01 Aug 2020| PMID: 32352834 | PMCID: PMC7427383 | DOI: 10.1164/rccm.202003-0510OC

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis.
Gill D, Georgakis MK, Zuber V, Karhunen V, Burgess S, Malik R, Dichgans M
J Am Heart Assoc, 9(14):e016773, 04 Jul 2020| PMID: 32627641 | PMCID: PMC7660704 | DOI: 10.1161/JAHA.120.016773

A Mendelian randomization of γ' and total fibrinogen levels on venous thromboembolism and ischemic stroke.
Maners J, Gill D, Pankratz N, Laffan MA, Wolberg AS, de Maat MPM, Ligthart S, Tang W, Ward-Caviness CK, Fornage M, Debette S, Dichgans M, McKnight B, Boerwinkle E, Smith NL, Morrison A, Dehghan A, de Vries PS.
Blood. 2020 Dec 24 | PMID: 33367543 | PMCID: PMC7770565 | DOI: 10.1182/blood.2019004781

Genetically Predicted Blood Pressure Across the Lifespan: Differential Effects of Mean and Pulse Pressure on Stroke Risk.
Georgakis MK, Gill D, Malik R, Protogerou AD, Webb AJS, Dichgans M
Hypertension, 76(3):953-961, 06 Jul 2020| PMID: 32623925 | PMCID: PMC7418931 | DOI: 10.1161/HYPERTENSIONAHA.120.15136

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease.
Zuber V, Gill D, Ala-Korpela M, Langenberg C, Butterworth A, Bottolo L, Burgess S
Int J Epidemiol, 50(3):893-901, 01 Jul 2021| PMID: 33130851 | PMCID: PMC8271202 | DOI: 10.1093/ije/dyaa216

A Semi-Automatic Method To Segment The Left Atrium in MR Volumes With Varying Slice Numbers.
Uslu F, Varela M, Bharath AA
Annu Int Conf IEEE Eng Med Biol Soc, 2020:1198-1202, 01 Jul 2020| PMID: 33018202 | DOI: 10.1109/EMBC44109.2020.9175749

Discriminating electrocardiographic responses to His-bundle pacing using machine learning.
Arnold AD, Howard JP, Gopi AA, Chan CP, Ali N, Keene D, Shun-Shin MJ, Ahmad Y, Wright IJ, Ng FS, Linton NWF, Kanagaratnam P, Peters NS, Rueckert D, Francis DP, Whinnett ZI
Cardiovasc Digit Health J, 1(1):11-20, 01 Jul 2020| PMID: 32954375 | PMCID: PMC7484933 | DOI: 10.1016/j.cvdhj.2020.07.001

Understanding the transition from paroxysmal to persistent atrial fibrillation.
Ciacci A, Falkenberg M, Manani KA, Evans TS, Peters NS, Christensen K
Phys Rev Res, 2(2):023311, 09 Jun 2020| PMID: 32607500 | PMCID: PMC7326608 | DOI: 10.1103/PhysRevResearch.2.023311

Repositioning of the global epicentre of non-optimal cholesterol.
NCD Risk Factor Collaboration (NCD-RisC), Ezzati et al
Nature, 582(7810):73-77, 03 Jun 2020| PMID: 32494083 | PMCID: PMC7332422 | DOI: 10.1038/s41586-020-2338-1

Feasibility of Estimation of Aortic Wave Intensity Using Non-invasive Pressure Recordings in the Absence of Flow Velocity in Man.
Hughes AD, Park C, Ramakrishnan A, Mayet J, Chaturvedi N, Parker KH.
Front Physiol. 2020 May 25 | PMID: 32528317 | PMCID: PMC7260344 | DOI: 10.3389/fphys.2020.00550

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study.
Georgakis MK, Malik R, Gill D, Franceschini N, Sudlow CLM, Dichgans M, INVENT Consortium,CHARGE Inflammation Working Group
Circ Genom Precis Med, 13(3):e002872, 12 May 2020| PMID: 32397738 | PMCID: PMC7299212 | DOI: 10.1161/CIRCGEN.119.002872

Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation.
Moroz-Omori EV, Satyapertiwi D, Ramel MC, Høgset H, Sunyovszki IK, Liu Z, Wojciechowski JP, Zhang Y, Grigsby CL, Brito L, Bugeon L, Dallman MJ, Stevens MM -ACS Cent Sci, 6(5):695-703, 01 Apr 2020| PMID: 32490186 | PMCID: PMC7256956 | DOI: 10.1021/acscentsci.9b01093

Repositioning of the global epicentre of non-optimal cholesterol
Ezzati, Majid,
Nature, June 2020 | PMID: 32494083 | PMCID: PMC7332422 | DOI: 10.1038/s41586-020-2338-1

Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension.
Ulrich A, Wharton J, Thayer TE, Swietlik EM, Assad TR, Desai AA, Gräf S, Harbaum L, Humbert M, Morrell NW, Nichols WC, Soubrier F, Southgate L, Trégouët DA, Trembath RC, Brittain EL, Wilkins MR, Prokopenko I, Rhodes CJ, [...] US PAH Biobank Consortium
Eur Respir J, 55(2), 12 Feb 2020| PMID: 31744833 | PMCID: PMC7015630 | DOI: 10.1183/13993003.01486-2019

Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR
Am J Respir Crit Care Med, 201(2):224-239, 01 Jan 2020| PMID: 31545648 | PMCID: PMC6961733 | DOI: 10.1164/rccm.201903-0591OC

REal-time Assessment of Community Transmission (REACT) of SARS-CoV-2 virus: Study protocol [version 2; peer review: 2 approved]
Riley S, Atchison C, Ashby D, Donnelly C, Barclay W, Cooke G, Ward H, Darzi A, Elliott P, REACT study group
Wellcome Open Res, 5, 01 Jan 2020| PMID: 33997297 | PMCID: PMC8095190 | DOI: 10.12688/wellcomeopenres.16228.2

Publications 2019

Unified mechanism of local drivers in a percolation model of atrial fibrillation.
Falkenberg M, Ford AJ, Li AC, Lawrence R, Ciacci A, Peters NS, Christensen K
Phys Rev E, 100(6-1):062406, 01 Dec 2019| PMID: 31962501 | PMCID: PMC7314598 | DOI: 10.1103/PhysRevE.100.062406

Publications from 2018 

Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.
Biffi C, de Marvao A, Attard MI, Dawes TJW, Whiffin N, Bai W, Shi W, Francis C, Meyer H, Buchan R, Cook SA, Rueckert D, O'Regan DP.
Bioinformatics 2018;34(1):97-103 | PMID: 28968671 | PMCID: PMC5870605 | DOI: 10.1093/bioinformatics/btx552

Aortic Dilatation in Repaired Tetralogy of Fallot. JACC Cardiovasc Imaging.
Bonello B, Shore DF, Uebing A, Diller GP, Keegan J, Burman ED, Shiina Y, Swan L, Pennell DJ, Kilner PJ, Beurtheret S, Gatzoulis MA, Babu-Narayan SV.
JACC Cardiovasc Imaging, 2018 Jan;11(1):150-152. Epub 2017 Apr 12. | PubMed PMID: 28412425 |  DOI: 10.1016/j.jcmg.2017.01.021

Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line. (In review)
Charles Houston, Konstantinos N Tzortzis, Caroline Roney, Andrea Saglietto, David S Pitcher, Chris Cantwell, Rasheda A Chowdhury, Fu Siong Ng, Nicholas S Peters, Emmanuel Dupont.
J Mol Cell Cardiol. 2018 Jun | PMID: 29746849 | PMCID: PMC6004038 | DOI: 10.1016/j.yjmcc.2018.05.002

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients with Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction
Halliday BP, Pennell DJ, Prasad SK. Response by Halliday et al to Letter Regarding Article.
Circulation. 2018 Jan 2;137(1):101-102 | PubMed PMID: 29279345 | DOI: 10.1161/CIRCULATIONAHA.117.032053

What is CMR doing for patients today? 
Khalique Z, Pennell DJ.
Eur Heart J. 2018 Jan 21;39(4):266-270 | PubMed PMID: 29365112 | DOI: 10.1093/eurheartj/ehx778

An in-vivo comparison of stimulated-echo and motion compensated spin-echo sequences for 3 T diffusion tensor cardiovascular magnetic  resonance at multiple cardiac phases.
Scott AD, Nielles-Vallespin S, Ferreira PF, Khalique Z, Gatehouse PD, Kilner P, Pennell DJ, Firmin DN.
J Cardiovasc Magn Reson. 2018 Jan 3;20(1):1 | PubMed PMID: 29298692; | PMCID: PMC5753538 | DOI: 10.1186/s12968-017-0425-8

Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.
Sheehan, A., Messer, A.E., Papadaki, M., Choudhry, A., Kren, V., Biedermann, D., Blagg, B., Khandelwal, A. and Marston, S.B.
Front Physiol, 2018 Mar 27; 9:243 | PMID: 29636697 | PMCID: PMC5881522 | DOI: 10.3389/fphys.2018.00243

Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T (1) mapping: averaging to improve precision and correlation with collagen volume fraction.
Vassiliou VS, Wassilew K, Cameron D, Heng EL, Nyktari E, Asimakopoulos G, de  Souza A, Giri S, Pierce I, Jabbour A, Firmin D, Frenneaux M, Gatehouse P, Pennell DJ, Prasad SK.
MAGMA. 2018 Feb;31(1):101-113. Epub 2017 Jun 12 | PMID: 28608326 | PMCID: PMC5813064 | DOI: 10.1007/s10334-017-0630-3

Deranged Myocyte Microstructure in Situs Inversus Totalis Demonstrated by Diffusion Tensor Cardiac Magnetic Resonance.
Khalique Z, Ferreira PF, Scott AD, Nielles-Vallespin S, Kilner PJ, Kutys R, Romero M, Arai AE, Firmin DN, Pennell DJ.
JACC Cardiovasc Imaging. 2018 Jan 12. pii: S1936-878X(17)31083-5.  [Epub ahead of print] | PMID: 29361490 | DOI: 10.1016/j.jcmg.2017.11.014

Publications from 2017

Air pollution and cardiovascular mortality with over 25years follow-up: A combined analysis of two British cohorts.
Dehbi HM, Blangiardo M, Gulliver J, Fecht D, de Hoogh K, Al-Kanaani Z, Tillin T, Hardy R, Chaturvedi N, Hansell AL. 
Environ Int. 2017 Feb; 99:275-281 | PMID: 27939045 | PMCID: PMC5292102 | DOI: 10.1016/j.envint.2016.12.004

Characterization and consistency of interactions of triggers and substrate at the onset of paroxysmal atrial fibrillation.
Jones DG, Markides V, Chow AW, Schilling RJ, Kanagaratnam P, Wong T, Davies DW and Peters, NS.
Europace. 2017 Jan 25 | PubMed PMID: 28339601| DOI: 10.1093/europace/euw229

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.
Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW.
Chem Commun (Camb). 2017 May 4;53(37):5182-5185 | PMID: 28439590 | PMCID: PMC6034444 | DOI: 10.1039/c6cc08797c

Development of an automaton model of rotational activity driving atrial fibrillation.
Ciaccio EJ, Biviano AB, Wan EY, Peters NS, Garan H.
Comput Biol Med. 2017 Apr 1;83:166-181 | Epub 2017 Mar 2 | PubMed PMID: 28282592 | DOI: 10.1016/j.compbiomed.2017.02.008

Multi-modal hydrogel platform to enhance and monitor cardiac progenitor/stem cell engraftment.
Speidel AT, Stuckey DJ, Chow LW, Jackson L, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM.
ACS Cent Sci. 2017 Apr 26;3(4):338-348 | PMID:28470052 | PMCID: PMC5408339 | DOI: 10.1021/acscentsci.7b00039

Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media.
Chooi KY, Comerford A, Sherwin SJ, Weinberg PD.
J Biomech. 2017 Mar 21;54:4-10. | PMID: 28256247 | PMCID: PMC5380660 | DOI: 10.1016/j.jbiomech.2017.01.027

Rotor Tracking Using Phase of Electrograms Recorded During Atrial Fibrillation.
Roney CH, Cantwell CD, Qureshi NA, Chowdhury RA, Dupont E, Lim PB, Vigmond EJ, Thomas NM, Gray R, Fry CH, Desplantez T, Peters NS, Severs NJ, Macleod KT, Tweedy JH, Ng FS, Peters NS.
Ann Biomed Eng. 2017 Apr;45(4):910-923 | Epub 2016 Dec 5 | PubMed PMID: 27921187 | PMCID: PMC5362653 | DOI: 10.1007/s10439-016-1766-4

Titin-truncating variants affect heart function in disease cohorts and the general population.
Schafer A, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJW, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik KP, O'Regan D, Ware JS, Hubner N, Cook SA.
Nat Genet. 2017 Jan;49(1):46-53 | Epub 2016 Nov 21 | PubMed PMID: 26911995 | PMCID: PMC4766560 | DOI: 10.1038/srep21785

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.
Duluc L, Ahmetaj-Shala B, Mitchell J, Abdul Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L, Dubois OD, Storck EM, Tate EW, Zhao L, Wilkins MR, Wojciak-Stothard B (2017).
Cardiovasc Res. 2017 Mar 1;113(3):276-287 | PMID: 28395021 | PMCID: PMC5408956 | DOI: 10.1093/cvr/cvw258

Understanding the fluid mechanics behind transverse wall shear stress.
Mohamied Y, Sherwin SJ and Weinberg PD.
J Biomech. 2017 Jan 4;50:102-109 | PMID: 27863740 | PMCID: PMC5236061 | DOI: 10.1016/j.jbiomech.2016.11.035

Publications from 2016

A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behcet's Syndrome.
Khan E, Ambrose NL, Ahnstrom J, Kiprianos AP, Stanford MR, Eleftheriou D, Brogan PA, Mason JC, Johns M, Laffan MA, Haskard DO.
Sci Rep. 2016 Dec 7;6:38104 | PubMed PMID: 27924945 | PMCID: PMC5141484 | DOI: 10.1038/srep38104

A Prospective Study of Ripple Mapping in Atrial Tachycardias: A Novel Approach to Interpreting Activation in Low-Voltage Areas.
Luther V, Linton NW, Koa-Wing M, Lim PB, Jamil-Copley S, Qureshi N, Ng FS, Hayat S, Whinnett Z, Davies DW, Peters NS, Kanagaratnam P.
Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003582 | PMID: 26757985 | DOI: 10.1161/CIRCEP.115.003582

A Prospective Study of Ripple Mapping the Post-Infarct Ventricular Scar to Guide Substrate Ablation for Ventricular Tachycardia.
Luther V, Linton NW, Jamil-Copley S, Koa-Wing M, Lim PB, Qureshi N, Ng FS, Hayat S, Whinnett Z, Davies DW, Peters NS, Kanagaratnam P.
Circ Arrhythm Electrophysiol. 2016 Jun;9(6). pii: e004072. | PMID: 27307519 | DOI: 10.1161/CIRCEP.116.004072

An array of individually addressable micro-needles for mapping pH distributions.
Zuliani C, Ng FS, Alenda A, Eftekhar A, Peters NS, Toumazou C.
Analyst. 2016 Aug 7;141(15):4659-66 | PMID: 27243147 | DOI: 10.1039/c6an00639f

Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function.
Jones S, Lumens J, Sohaib SM, Finegold JA, Kanagaratnam P, Tanner M, Duncan E, Moore P, Leyva F, Frenneaux M, Mason M, Hughes AD, Francis DP, Whinnett ZI, BRAVO Investigators, Peters NS et al
Europace. 2016 Jul 13. pii: euw136. PubMed PMID: 27411361 | PMCID: PMC5834145 | DOI: 10.1093/europace/euw136

Ectopy-Triggering Ganglionated Plexus Sites May Be An Alternative Target For Atrial Fibrillation Ablation.
Sikkel MB,B Sandler, PB Lim, L Malcolme-Lawes, I Mann, V Luther, S Sohaib, FS Ng, I Wright, N Qureshi, K Leong, M Koa-Wing, Z Whinnett, DW Davies, NS Peters, N Linton, P Kanagaratnam.
Heart Rhythm  13(5): S1-S688.

Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility.
Ng FS, Kalindjian JM, Cooper SA, Chowdhury RA, Patel PM, Dupont E, Lyon AR, Peters NS.
JACC Clin Electrophysiol 2(5):574-582. PMID: 27807593 | PMCID: PMC5076465 | DOI: 10.1016/j.jacep.2016.03.007

Formation of Functional Conduction Block during the Onset of Reentrant Ventricular Tachycardia.
Ciaccio EJ, Coromilas J, Wit AL, Peters NS, Garan H.
Circ Arrhythm Electrophysiol. 2016 Dec;9(12). pii: e004462. PubMed PMID: 27879278 | DOI: 10.1161/CIRCEP.116.004462

Formation of re-entrant circuits in the mid-myocardial infarct border zone.
Ciaccio EJ, Coromilas J, Wit AL, Peters NS, Garan H.
Comput Biol Med. 2016 Apr 1;71:205-13 | Epub 2016 Feb 22 | PubMed PMID: 26945600 | DOI: 10.1016/j.compbiomed.2016.02.009

Heartbreak hotel: a convergence in cardiac regeneration.
Schneider MD.
Development. 2016 May 1;143(9):1435-41 | PMID: 27143752 | DOI: 10.1242/dev.133652

High Serum Immunoglobulin G and M Levels Predict Freedom from Adverse Cardiovascular Events in Hypertension: A Nested Case-Control Substudy of the Anglo-Scandinavian Cardiac Outcomes Trial.
Khamis RY, Hughes AD, Caga-Anan M, Chang CL, Boyle JJ, Kojima C, Welsh P, Sattar N, Johns M, Sever P, Mayet J, Haskard DO.
EBioMedicine. 2016 Jul;9:372-80. doi: 10.1016/j.ebiom.2016.06.012. Epub 2016 Jun 20. PubMed PMID: 27333022

Intimal and medial contributions to the hydraulic resistance of the arterial wall at different pressures: a combined computational and experimental study.
Chooi KY, Comerford A, Sherwin SJ, Weinberg PD. 
J R Soc Interface. 2016 Jun;13(119). pii: 20160234 | PMID: 27307514 | PMCID: PMC4938088 | DOI: 10.1098/rsif.2016.0234

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation.
Thornton CC, Al-Rashed F, Calay D, Birdsey GM, Bauer A, Mylroie H, Morley BJ, Randi AM, Haskard DO, Boyle JJ, Mason JC.
Ann Rheum Dis. 2016 Feb;75(2):439-48 | Epub 2015 Jan 9. PubMed PMID: 25575725 | PMCID: PMC4752671 | DOI: 10.1136/annrheumdis-2014-206305

Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial.
Nguyen BA, Fiorentino F, Reeves BC, Baig K, Athanasiou T, Anderson JR, Haskard DO, Angelini GD, Evans PC.
Ann Thorac Surg. 2016 Apr;101(4):1454-63 | Epub 2015 Nov 18. PubMed PMID: 26602006 | DOI: 10.1016/j.athoracsur.2015.09.029

Multimodal Hydrogel-Based Platform to Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.
Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM.
Development. 2016 May 1;143(9):1435-41. doi: 10.1242/dev.133652. PMID: 28470052 | PMCID: PMC5408339 | DOI: 10.1021/acscentsci.7b00039

Myocardial architecture and patient variability in clinical patterns of atrial fibrillation.
Manani KA, Christensen K, Peters NS (2016).
 Phys Rev E. 2016 Oct;94(4-1):042401. PMID: 27841583 | DOI: 10.1103/PhysRevE.94.042401

Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis.
Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Chang SH, Malik TH, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DO.
Sci Rep. 2016 Feb 25;6:21785. | PubMed PMID: 26911995 | PMCID: PMC4766560 | DOI: 10.1038/srep21785

New paradigms in cardiovascular calcification.

Agarwal S and Bertazzo S (2016). 
Comptes Rendus Chimie, 19(11), pp.1605-1609.  

Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium.

Zaman JA, Harling L, Ashrafian H, Darzi A, Gooderham N, Athanasiou T, Peters NS.
Int J Cardiol. 2016 Oct 1;220:580-8 | PMID: 27390994 | PMCID: PMC4994770 | DOI: 10.1016/j.ijcard.2016.06.249

Role of endothelial permeability hotspots and endothelial mitosis in determining age-related patterns of macromolecule uptake by the rabbit aortic wall near branch points.
Chooi KY, Comerford A, Cremers SJ, Weinberg PD.
Atherosclerosis. 2016 Jul;250:77-83 | PMID: 27182961 | PMCID: PMC4917891 | DOI: 10.1016/j.atherosclerosis.2016.05.017

Systemic autoimmunity induced by Toll-like receptor 7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy; a new model of autoimmune heart disease.
Hasham MG, Baxan N, Stuckey DJ, Dent O, Branca J, Perkins BRA, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N, Sattler S.
Dis Model Mech. 2017 Mar 1;10(3):259-270 |  PMID: 28250051 | PMCID: PMC5374321 | DOI: 10.1242/dmm.027409

Zebrafish Model for Functional Screening of Flow-Responsive Genes.
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton JP, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJ, Evans PC.
Ann Thorac Surg. 2016 Apr;101(4):1454-63. | Epub 2015 Nov 18 | PubMed PMID: 26602006 | DOI: 10.1016/j.athoracsur.2015.09.029

A Targeting Microbubble for Ultrasound Molecular Imaging.
Yeh JS, Sennoga CA, McConnell E, Eckersley R, Tang MX, Nourshargh S, Seddon JM, Haskard DO, Nihoyannopoulos P.
PLoS One. 2015 Jul 10;10(7):e0129681. doi:10.1371/journal.pone.0129681.
eCollection 2015. PubMed PMID: 26161541; PubMed Central PMCID: PMC4498921.

Low shear stress induces M1 macrophage polarisation in murine thin-cap atherosclerotic plaques.
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R, Monaco C.
J Mol Cell Cardiol. 2015 Dec;89(Pt B):168-72. doi: 10.1016/j.yjmcc.2015.10.034. Epub 2015 Oct 30. PubMed PMID: 26523517.

A technique for visualising three-dimensional left atrial cardiac activation data in two dimensions with minimal distance distortion.
Roney CH, Tzortzis KN, Cantwell CD, Qureshi NA, Ali RL, Phang Boon Lim, Siggers JH, Fu Siong Ng, Peters NS.
Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:7296-9. doi:10.1109/EMBC.2015.7320076. PubMed PMID: 26737976.

Autologous dermal fibroblast injections slow atrioventricular conduction and ventricular rate in atrial fibrillation in swine.
Tondato F, Zeng H, Goodchild T, Ng FS, Chronos N, Peters NS.
Circ Arrhythm Electrophysiol. 2015 Apr;8(2):439-46.
doi: 10.1161/CIRCEP.114.001536. Epub 2015 Jan 31. PubMed PMID: 25638212.

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.
Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith AJ, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, Schneider MD.
Nat Commun. 2015 May 18;6:6930. doi: 10.1038/ncomms7930. PubMed PMID: 25980517.

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knöll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, López-Olañeta MM, Gómez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schäfer S, Hübner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knöll R.
Circ Cardiovasc Genet. 2015 Oct;8(5):643-52. doi: 10.1161/CIRCGENETICS.113.000690. Epub 2015 Jul 14. PubMed PMID: 26175529.

Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction.
Gallego-Colon E, Sampson RD, Sattler S, Schneider MD, Rosenthal N, Tonkin J.
Mediators Inflamm. 2015;2015:484357. doi: 10.1155/2015/484357. Epub 2015 Sep 30. PubMed PMID: 26491228.

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization.
Tonkin J, Temmerman L, Sampson RD, Gallego-Colon E, Barberi L, Bilbao D, Schneider MD, Musarò A, Rosenthal N. 
Mol Ther. 2015 Jul;23(7):1189-200. doi: 10.1038/mt.2015.66. Epub 2015 Apr 21. PubMed PMID: 25896247.

Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5.
Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD.
PLoS One. 2015 Jun 5;10(6):e0125384. doi: 10.1371/journal.pone.0125384.
eCollection 2015. PubMed PMID: 26047103.

Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues.
Morez C, Noseda M, Paiva MA, Belian E, Schneider MD, Stevens MM.
Biomaterials. 2015 Nov;70:94-104. doi:10.1016/j.biomaterials.2015.07.063. Epub 2015 Aug 8. PubMed PMID: 26302234.

Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties.
Rowland EM, Mohamied Y, Yean Chooi K, Bailey EL, Weinberg PD.
J Biomech Eng. 2015 Oct;137(10):101003. doi:10.1115/1.4031119. PubMed PMID: 26201866.

A combined numerical and experimental framework for determining permeability properties of the arterial media.
Comerford A, Chooi KY, Nowak M, Weinberg PD, Sherwin SJ.
Biomech Model Mechanobiol. 2015 Apr;14(2):297-313. doi:10.1007/s10237-014-0604-6. Epub 2014 Jul 17. PubMed PMID: 25027803.