@article{Zhang:2026,
author = {Zhang, T and Wei, Q and Schmit, N},
journal = {EClinicalMedicine},
title = {Post-acute sequelae after Nipah virus infection: a systematic review and meta-analysis},
year = {2026}
}

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TY  - JOUR
AB  - Background Nipah virus was first detected in the 1998-1999 Malaysia outbreak and remains a significant public health concern due to its high epidemic potential and recurrent outbreaks in South Asia. Incidence patterns of post-acute sequelae, characterised by persistence or delayed onset after the acute phase of an infection, are not well documented after infectious disease outbreaks. We aimed to address this knowledge gap. Methods We conducted a systematic review and meta-analysis on the prevalence, incidence, duration, and characteristics of post-acute sequelae in survivors of Nipah virus infection. We searched PubMed and Web of Science for studies published in English between database inception and Nov 17, 2025. Articles were eligible for inclusion if they were peer-reviewed and reported primary data on post-acute sequelae in survivors of Nipah virus infection. Risk of bias was assessed using Joanna Briggs Institute critical appraisal tools. We conducted random-effects meta-analysis for all outcomes reported in at least two studies, and assessed heterogeneity qualitatively and using the I2 statistic. This review was registered with PROSPERO CRD42024616198. Findings Our search identified 1,091 articles after deduplication, of which eight were eligible for inclusion in the systematic review and six in the meta-analysis. Study populations included hospitalised Nipah encephalitis survivors and total survivors of Nipah virus infection in three and five articles, respectively. Only one study included a healthy control group. Three articles were of high, four of moderate and one of low quality. We extracted prevalence for potential neurological, psychiatric or non-specific post-acute sequelae. The pooled prevalence of total residual neurological deficits was 24% (95% CI 9-49; I2=0%) among total survivors of Nipah infection (3 studies; 80 participants), and 45% (95% CI 11-85; I2=64%) among the subset of survivors with acute Nipah encephalitis (3 studies; 87 participants).
AU  - Zhang,T
AU  - Wei,Q
AU  - Schmit,N
PY  - 2026///
SN  - 2589-5370
TI  - Post-acute sequelae after Nipah virus infection: a systematic review and meta-analysis
T2  - EClinicalMedicine
ER  - 

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