@article{Gonzalez-Estrada:2026:10.1016/j.waojou.2026.101362,
author = {Gonzalez-Estrada, A and Estrada-Mendizabal, RJ and Ansotegui, IJ and Campbell, DE and Carr, S and Cardona, V and Ebisawa, M and Geller, M and Worm, M and Greenberger, PA and Leung, ASY and Levin, ME and Morais-Almeida, M and Muraro, A and Ortega-Martell, JA and Pouessel, G and Senna, G and Turner, PJ and Tanno, LK and WAO, Anaphylaxis committee},
doi = {10.1016/j.waojou.2026.101362},
journal = {World Allergy Organ J},
title = {World Allergy Organization survey on the diagnosis and management trends of perioperative anaphylaxis.},
url = {http://dx.doi.org/10.1016/j.waojou.2026.101362},
volume = {19},
year = {2026}
}

Download

TY  - JOUR
AB  - BACKGROUND: Perioperative anaphylaxis (POA) is a life-threatening condition with substantial variability in evaluation and management practices. OBJECTIVE: To assess current practices, perceived barriers, and regional differences in POA management among allergists worldwide. METHODS: A cross-sectional online survey was distributed to World Allergy Organization (WAO) members from March to June 2024. The 39-question survey addressed demographics, clinical practices, diagnostic tools, perceived challenges, and future needs. RESULTS: A total of 249 respondents from 50 countries completed the survey (median age 49 years, 49% female, 94% allergists, and 57% with >15 years of clinical experience). While 70% had access to acute serum tryptase (sAT), only 46% obtained it within the recommended 2-h window. Guideline adherence was low: 63% did not perform skin testing 4-6 weeks post-reaction, and fewer than half routinely tested for latex or chlorhexidine. Regional differences were observed: routine latex and chlorhexidine testing was most common in Europe and United States/Canada and least frequent in Africa and Asia (p = 0.0001); tryptase availability was lower in Africa and Latin America. Most respondents identified a culprit in <65% of cases, with antibiotics reported most frequently in Europe and United States/Canada, followed by neuromuscular blocking agents and non-steroidal anti-inflammatory drugs (NSAIDs). Major barriers included limited access to anesthesia records, testing reagents, and resource-related contrainsts in low-income regions. Respondents expressed the need for guidelines on alternative agents and validated non-irritating skin test concentrations. CONCLUSIONS: This international survey highlights substantial regional differences and global barriers in POA evaluation. Improving access to diagnostic resources, enhancing interdisciplinary collaboration, and providing clear guidance on alternative agents and standardized testing methods are essential to
AU  - Gonzalez-Estrada,A
AU  - Estrada-Mendizabal,RJ
AU  - Ansotegui,IJ
AU  - Campbell,DE
AU  - Carr,S
AU  - Cardona,V
AU  - Ebisawa,M
AU  - Geller,M
AU  - Worm,M
AU  - Greenberger,PA
AU  - Leung,ASY
AU  - Levin,ME
AU  - Morais-Almeida,M
AU  - Muraro,A
AU  - Ortega-Martell,JA
AU  - Pouessel,G
AU  - Senna,G
AU  - Turner,PJ
AU  - Tanno,LK
AU  - WAO,Anaphylaxis committee
DO  - 10.1016/j.waojou.2026.101362
PY  - 2026///
SN  - 1939-4551
TI  - World Allergy Organization survey on the diagnosis and management trends of perioperative anaphylaxis.
T2  - World Allergy Organ J
UR  - http://dx.doi.org/10.1016/j.waojou.2026.101362
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41938649
VL  - 19
ER  - 

Download