@article{Stölting:2026:10.1126/sciimmunol.adk1673,
author = {Stölting, H and Raftery, AL and Walker, SA and Rutherford, EN and Gore, ML and Huang, Y and Puttur, F and Yates, L and Saglani, S and Lloyd, CM},
doi = {10.1126/sciimmunol.adk1673},
journal = {Sci Immunol},
title = {Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen.},
url = {http://dx.doi.org/10.1126/sciimmunol.adk1673},
volume = {11},
year = {2026}
}

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TY  - JOUR
AB  - Hormonal disruptions are associated with poor asthma control in females, yet how these phenomena are linked remains unknown. Here, we investigated distinct allergen-induced immune responses between the sexes during maturation. By 6 weeks of life, female mice exposed to the aeroallergen house dust mite (HDM) from postnatal day 7 exhibited stronger type 2 (T2) immune responses and higher lung interleukin-33 (IL-33) than males. IL-33 administration to HDM-sensitized males was sufficient to augment T2 immunity and up-regulated epidermal growth factor receptor (EGFR) on T helper 2 (TH2) cells. EGFR inhibition abrogated T2 cytokine production in vitro. In vivo, EGFR inhibition reduced T2 immunity in females only, thereby abolishing any sex differences. 17β-estradiol (E2) heightened lung Il33 expression and T2 responses of HDM-sensitized males, akin to levels in females. EGFR's ability to drive sex differences in lung T2 responses downstream of E2 and IL-33 may link hormonal disruptions to poor asthma control.
AU  - Stölting,H
AU  - Raftery,AL
AU  - Walker,SA
AU  - Rutherford,EN
AU  - Gore,ML
AU  - Huang,Y
AU  - Puttur,F
AU  - Yates,L
AU  - Saglani,S
AU  - Lloyd,CM
DO  - 10.1126/sciimmunol.adk1673
PY  - 2026///
TI  - Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen.
T2  - Sci Immunol
UR  - http://dx.doi.org/10.1126/sciimmunol.adk1673
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41576136
VL  - 11
ER  - 

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