@article{Rowbotham:2026:10.1136/thorax-2025-224469,
author = {Rowbotham, NJ and Jeanpierre, M and Bush, A and Jagani, S and Jones, G and Warrier, K and Parlato, M and Rieux-Laucat, F and Bhatt, JM},
doi = {10.1136/thorax-2025-224469},
journal = {Thorax},
title = {New pathogenic PTPN2 variant leading to childhood interstitial lung disease.},
url = {http://dx.doi.org/10.1136/thorax-2025-224469},
year = {2026}
}

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TY  - JOUR
AB  - Protein tyrosine phosphatase non-receptor type 2 (PTPN2) is a tyrosine phosphatase involved in T cell receptor signal transduction and cytokine response. Loss of function variants have previously been linked with immune mediated diseases such as inflammatory bowel disorders, rheumatoid arthritis and type 1 diabetes. We present a case of childhood interstitial lung disease with a newly identified pathogenic (PTPN2) gene variant in a boy aged 4 years.
AU  - Rowbotham,NJ
AU  - Jeanpierre,M
AU  - Bush,A
AU  - Jagani,S
AU  - Jones,G
AU  - Warrier,K
AU  - Parlato,M
AU  - Rieux-Laucat,F
AU  - Bhatt,JM
DO  - 10.1136/thorax-2025-224469
PY  - 2026///
TI  - New pathogenic PTPN2 variant leading to childhood interstitial lung disease.
T2  - Thorax
UR  - http://dx.doi.org/10.1136/thorax-2025-224469
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41545210
ER  - 

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