@article{Stewart:2026:10.1016/j.ebiom.2026.106134,
author = {Stewart, I and John, A and Bin, L and Fabbri, L and Mitchell, J and Molyneaux, P and Quinn, V and Smith, D and Walsh, S and Quint, J and Jenkins, G and Chalmers, J and Chambers, R and Britghtling, C and Wain, L and Elneima, O and Evans, R and Greening, N and Harris, V and Horsley, A and Houchen-Wolloff, L and Leavy, O and Marks, M and McAuley, H and Poinasamy, K and Raman, B and Richardson, M and Saunders, R and Sereno, M and Shikotra, A and Singapuri, A and Young, S and Stephens, A and Pohl, M and Maslova, A and Lone, N and Harrison, E and Greenhalf, W and Gleeson, F and Docherty, A and Wootton, D and Wild, J and Thompson, R and Stanel, S and Spencer, L and Spears, M and Saunders, L and Rivera-Ortega, P and Plate, M and Piper, Hanley K and Pearl, J and Mehta, P and Khan, F and Jones, M and Johnson, S and Jarrold, I and Ho, L-P and Hall, I and Gooptu, B and Guillen-Guio, B and George, P and Denneny, E and Chaudhuri, N and Blaikley, J and Allen, R and Pugh, M and Gomez, N and Tatler, A },
doi = {10.1016/j.ebiom.2026.106134},
journal = {EBioMedicine},
title = {Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury},
url = {http://dx.doi.org/10.1016/j.ebiom.2026.106134},
volume = {124},
year = {2026}
}

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TY  - JOUR
AB  - Some survivors of acute COVID-19 infection have long-term symptoms that could suggest ongoing lung impairment. Searches performed in MEDLINE and Embase for SARS-COV-2 studies with radiological lung follow-up estimated that 50% of participants had inflammatory patterns and 29% had fibrotic patterns at a median of 3 months post infection. Analysis of the UK nationwide Post-hospitalisation COVID-19 Study at 5-months follow-up suggested that up to 11% of people discharged from hospital following COVID-19 infection were at-risk of radiological residual lung abnormalities, such as ground glass opacity and reticulation. In people with pulmonary fibrosis, these radiological patterns are often consistent with persistent epithelial lung injury. Biomarker studies have identified associations with COVID-19 severity, however there are few studies that explore the relationship between biomarkers of epithelial injury and parenchymal lung abnormalities post-hospitalisation.
AU  - Stewart,I
AU  - John,A
AU  - Bin,L
AU  - Fabbri,L
AU  - Mitchell,J
AU  - Molyneaux,P
AU  - Quinn,V
AU  - Smith,D
AU  - Walsh,S
AU  - Quint,J
AU  - Jenkins,G
AU  - Chalmers,J
AU  - Chambers,R
AU  - Britghtling,C
AU  - Wain,L
AU  - Elneima,O
AU  - Evans,R
AU  - Greening,N
AU  - Harris,V
AU  - Horsley,A
AU  - Houchen-Wolloff,L
AU  - Leavy,O
AU  - Marks,M
AU  - McAuley,H
AU  - Poinasamy,K
AU  - Raman,B
AU  - Richardson,M
AU  - Saunders,R
AU  - Sereno,M
AU  - Shikotra,A
AU  - Singapuri,A
AU  - Young,S
AU  - Stephens,A
AU  - Pohl,M
AU  - Maslova,A
AU  - Lone,N
AU  - Harrison,E
AU  - Greenhalf,W
AU  - Gleeson,F
AU  - Docherty,A
AU  - Wootton,D
AU  - Wild,J
AU  - Thompson,R
AU  - Stanel,S
AU  - Spencer,L
AU  - Spears,M
AU  - Saunders,L
AU  - Rivera-Ortega,P
AU  - Plate,M
AU  - Piper,Hanley K
AU  - Pearl,J
AU  - Mehta,P
AU  - Khan,F
AU  - Jones,M
AU  - Johnson,S
AU  - Jarrold,I
AU  - Ho,L-P
AU  - Hall,I
AU  - Gooptu,B
AU  - Guillen-Guio,B
AU  - George,P
AU  - Denneny,E
AU  - Chaudhuri,N
AU  - Blaikley,J
AU  - Allen,R
AU  - Pugh,M
AU  - Gomez,N
AU  - Tatler,A
AU  - Porter,J
AU  - Jacob,J
DO  - 10.1016/j.ebiom.2026.106134
PY  - 2026///
SN  - 2352-3964
TI  - Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2026.106134
VL  - 124
ER  - 

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