@article{Kahai:2026:10.1016/j.chest.2025.09.021,
author = {Kahai, R and Castelli, G and Danzo, F and Ferreira, L and Srirangan, A and Morviducci, M and Mirabelli, FM and Kaenmuang, P and Roberts, C and Bax, S and Hewitt, RJ and Kokosi, M and Chua, F and Kouranos, V and Molyneaux, PL and George, PM and Jenkins, RG and Banya, W and Stock, CJW and Jones, S and Korff, G and Duncan, A and Wells, AU and Sestini, P and Renzoni, EA},
doi = {10.1016/j.chest.2025.09.021},
journal = {Chest},
pages = {687--697},
title = {Specialist Dietary Intervention in Patients With Fibrotic Interstitial Lung Disease Experiencing Unintentional Weight Loss: A Pilot Randomized Controlled Trial.},
url = {http://dx.doi.org/10.1016/j.chest.2025.09.021},
volume = {169},
year = {2026}
}

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TY  - JOUR
AB  - BACKGROUND: Weight loss in patients with fibrotic interstitial lung disease (F-ILD) is associated with poor prognosis, yet the impact of dietary input is unknown. RESEARCH QUESTION: What is the feasibility of a randomized controlled trial of specialist dietary intervention in F-ILD? STUDY DESIGN AND METHODS: Patients with F-ILD experiencing low weight or weight loss were randomized 1:1 to either a 12-week specialist dietary intervention or a dietary information sheet by computer-generated sequence using random block design with stratification by antifibrotic drugs. The primary outcome was feasibility of recruitment, randomization, and retention. A key predefined exploratory outcome was weight change from baseline. RESULTS: Of 128 screened patients, 40 patients (31%) were randomized, 19 to diet and 21 to control arm. The target number of patients was reached within 7 months, suggesting feasibility of a larger trial. All randomized patients completed the study. In the diet arm, 8 of 19 (42%) vs 1 of 21 (4.8%) participants in the control arm gained ≥ 1 kg at 12 weeks (OR, 14.2; 95% CI, 1.4-141.8; P = .02). Analysis of the exploratory outcome of weight change revealed that after a 4-week lag, the estimated rate of weight change between 4 and 12 weeks was -0.25 kg/month (95% CI, -0.61 to 0.12) in the control and +0.40 kg/month (95% CI, 0.02 to 0.78) in the diet group, with a difference of +0.65 kg/month (95% CI, 0.15 to 1.14) in favor of the diet group (P = .01). INTERPRETATION: Based on the encouraging results of this pilot trial of dietary intervention in F-ILD, a definitive multicenter randomized controlled trial is warranted. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov; No.: NCT06016959; URL: www. CLINICALTRIALS: gov).
AU  - Kahai,R
AU  - Castelli,G
AU  - Danzo,F
AU  - Ferreira,L
AU  - Srirangan,A
AU  - Morviducci,M
AU  - Mirabelli,FM
AU  - Kaenmuang,P
AU  - Roberts,C
AU  - Bax,S
AU  - Hewitt,RJ
AU  - Kokosi,M
AU  - Chua,F
AU  - Kouranos,V
AU  - Molyneaux,PL
AU  - George,PM
AU  - Jenkins,RG
AU  - Banya,W
AU  - Stock,CJW
AU  - Jones,S
AU  - Korff,G
AU  - Duncan,A
AU  - Wells,AU
AU  - Sestini,P
AU  - Renzoni,EA
DO  - 10.1016/j.chest.2025.09.021
EP  - 697
PY  - 2026///
SP  - 687
TI  - Specialist Dietary Intervention in Patients With Fibrotic Interstitial Lung Disease Experiencing Unintentional Weight Loss: A Pilot Randomized Controlled Trial.
T2  - Chest
UR  - http://dx.doi.org/10.1016/j.chest.2025.09.021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41015200
VL  - 169
ER  - 

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