@inbook{Chi:2026,
author = {Chi, S and Zhang, Y},
booktitle = {Inflammation},
editor = {Wang},
title = {ORMDL3 and Sphingolipid Metabolism in Human Airway Inflammatory Diseases},
year = {2026}
}

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TY  - CHAP
AB  - Sphingolipid species play important roles in maintaining the functions of human lungs. Genetic studies identified that the polymorphisms of the ORMDL3 gene on human chromosome 17 were strongly associated with airway inflammatory diseases. ORMDL3 has multiple functions in human epithelial cells: it regulates de novo sphingolipid synthesis, protein folding, glycolysis, and expression of human rhinovirus receptor intercellular adhesion molecule 1(ICAM-1). In this chapter, we will focus on sphingolipids’ metabolism in airway epithelium and illustrate how ORMDL3 regulates sphingolipid lipid metabolism, particularly on ceramides and sphingosine-1-prosphrate (S1P) for the signaling transduction in inflammatory response. We will explore the roles of sphingolipid species in airway diseases including asthma, chronic obstructive pulmonary disease (COPD), lung injury, lung fibrosis, and lung infections caused by viruses, bacteria, and fungi. Finally, we will discuss the potential therapeutic agents that work in sphingolipid pathways for lung inflammatory diseases.
AU  - Chi,S
AU  - Zhang,Y
PY  - 2026///
TI  - ORMDL3 and Sphingolipid Metabolism in Human Airway Inflammatory Diseases
T1  - Inflammation
ER  - 

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