@article{Luca:2025:10.1038/s41467-025-66358-8,
author = {Luca, E and Ibeh, N and Yamamoto, R and Liang, W and Bennett, D and Lin, V and Chen, J and Lovett, M and Dabdoub, A},
doi = {10.1038/s41467-025-66358-8},
journal = {Nat Commun},
title = {Revealing heterogeneity and damage response in the adult human utricle.},
url = {http://dx.doi.org/10.1038/s41467-025-66358-8},
volume = {17},
year = {2025}
}

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TY  - JOUR
AB  - The human utricle is a vestibular organ essential for balance, a function that declines with age. With the aging population projected to double to 2 billion by 2050 and no pharmaceutical or biological treatments available, balance disorders represent a significant unmet medical need. The utricle is composed of sensory and non-sensory cells, which are closely related. Non-sensory cells have limited capacity to regenerate sensory cells and, therefore, are a relevant therapeutic target. In this work, we profile the cellular and transcriptional landscape of the adult human utricle and its early response to ototoxic damage using bulk and single-cell RNA-sequencing of patient-derived samples. We identify six transcriptionally distinct non-sensory cell types, including a previously uncharacterized supporting cell-like population, demonstrating utricular heterogeneity. Following aminoglycoside-induced damage, we detect early transcriptional changes consistent with a capacity to respond to ototoxic damage within 24 hours and potentially initiate a regenerative response via an early-responding cell population, providing a foundation for regenerative strategies for balance recovery.
AU  - Luca,E
AU  - Ibeh,N
AU  - Yamamoto,R
AU  - Liang,W
AU  - Bennett,D
AU  - Lin,V
AU  - Chen,J
AU  - Lovett,M
AU  - Dabdoub,A
DO  - 10.1038/s41467-025-66358-8
PY  - 2025///
TI  - Revealing heterogeneity and damage response in the adult human utricle.
T2  - Nat Commun
UR  - http://dx.doi.org/10.1038/s41467-025-66358-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41372202
VL  - 17
ER  - 

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