@article{Konstantinou:2026:10.1097/HJH.0000000000004252,
author = {Konstantinou, K and Koumelli, A and Apostolos, A and Dimitriadis, K and Pappelis, K and Mantzouranis, E and Chrysohoou, C and Kasiakogias, A and Sakalidis, A and Tsioufis, P and Panoulas, V and Kalogeras, K and Nihoyannopoulos, P and Tousoulis, D and Tsioufis, K},
doi = {10.1097/HJH.0000000000004252},
journal = {J Hypertens},
pages = {662--672},
title = {Short-term and mid-term blood pressure variability in acute myocardial infarction: a prospective cohort study on in-hospital and long-term prognostic impact.},
url = {http://dx.doi.org/10.1097/HJH.0000000000004252},
volume = {44},
year = {2026}
}

Download

TY  - JOUR
AB  - INTRODUCTION: Blood pressure variability (BPV) is a prognostic marker in hypertension and coronary artery disease (CAD), but its role in acute myocardial infarction (AMI) remains unknown. This study assessed the association of short-term (24-h ambulatory BP monitoring, ABPM) and mid-term BPV with adverse in-hospital and long-term outcomes in AMI patients. METHODS: Mid-term BPV was calculated as the standard deviation (SD) of daily in-hospital BP readings; short-term BPV was measured by average real variability (ARV) from ABPM. Patients were evaluated as continuous variables and by quartiles (Q1-Q4). Logistic regression and Cox models assessed in-hospital and 3-year outcomes. RESULTS: In this prospective, single-center cohort, 441 of 677 AMI patients were included. Each 1mmHg rise in day-to-day systolic BPV (SBP-SD) increased in-hospital MACE risk by 24% [odds ratio (OR): 1.24, 95% confidence interval (CI): 1.17-1.31], with Q4 showing the highest risk (OR: 28.89, 95% CI: 8.58-97.28). ABPM-derived SBP-ARV predicted in-hospital mortality (OR: 1.58, 95% CI: 1.21-2.07) and MACE (OR: 1.35, 95% CI: 1.23-1.48). Diastolic ARV was linked to in-hospital myocardial infarction (MI), arrhythmias, and shock. At 3-year follow up, Q4 of SBP-SD showed higher risk of composite outcomes (hazard ratio: 29.88, 95% CI: 10.93-81.66) and all-cause mortality (hazard ratio: 11.85, 95% CI: 2.81-49.91). SBP-ARV independently predicted both all-cause mortality (hazard ratio: 1.37, 95% CI: 1.25-1.51) and adverse events (hazard ratio: 1.29, 95% CI: 1.22-1.36), while diastolic BPV was primarily associated with arrhythmias and heart failure hospitalization. CONCLUSION: Systolic BPV independently predicts in-hospital and long-term outcomes in AMI. BPV assessment may aid post-MI risk stratification and guide novel therapeutic strategies in this high-risk population.
AU  - Konstantinou,K
AU  - Koumelli,A
AU  - Apostolos,A
AU  - Dimitriadis,K
AU  - Pappelis,K
AU  - Mantzouranis,E
AU  - Chrysohoou,C
AU  - Kasiakogias,A
AU  - Sakalidis,A
AU  - Tsioufis,P
AU  - Panoulas,V
AU  - Kalogeras,K
AU  - Nihoyannopoulos,P
AU  - Tousoulis,D
AU  - Tsioufis,K
DO  - 10.1097/HJH.0000000000004252
EP  - 672
PY  - 2026///
SP  - 662
TI  - Short-term and mid-term blood pressure variability in acute myocardial infarction: a prospective cohort study on in-hospital and long-term prognostic impact.
T2  - J Hypertens
UR  - http://dx.doi.org/10.1097/HJH.0000000000004252
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41649060
VL  - 44
ER  - 

Download