@article{Xuan:2026:10.1002/advs.202412993,
author = {Xuan, S and Wu, Y and Liu, F and Fu, H and Meng, Y and Ou, Y and Yuan, X and Adcock, IM and Jia, M and Zeng, X and Yao, X},
doi = {10.1002/advs.202412993},
journal = {Adv Sci (Weinh)},
title = {CD207-Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease.},
url = {http://dx.doi.org/10.1002/advs.202412993},
year = {2026}
}

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TY  - JOUR
AB  - Emphysema remains a major challenge in the management of chronic obstructive pulmonary disease (COPD). This study identifies CD207-positive dendritic cells (CD207+ DCs) as pivotal mediators of emphysema progression. In patients with COPD, the abundance of CD207+ DCs in small airways correlates with both emphysema severity and lung function decline (FEV1%pred). In a murine emphysema model, adoptive transfer of CD207+ DCs reversed the attenuation of emphysema, inflammation and CD8+ T-cell expansion in CD207-knockout mice. Mechanistically, cigarette smoke-induced epithelial GM-CSF drives the expansion of CD207+ DCs. Upon activation by damage-associated molecular patterns (DAMPs), these DCs promote CD8+ T cell proliferation and activation via Birbeck granule-mediated MHC-I antigen cross-presentation. Collectively, these findings demonstrate that CD207+ DCs orchestrate a pathogenic CD8+ T-cell response in emphysema and represent a promising therapeutic target.
AU  - Xuan,S
AU  - Wu,Y
AU  - Liu,F
AU  - Fu,H
AU  - Meng,Y
AU  - Ou,Y
AU  - Yuan,X
AU  - Adcock,IM
AU  - Jia,M
AU  - Zeng,X
AU  - Yao,X
DO  - 10.1002/advs.202412993
PY  - 2026///
TI  - CD207-Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease.
T2  - Adv Sci (Weinh)
UR  - http://dx.doi.org/10.1002/advs.202412993
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41498703
ER  - 

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