Metabolic Medicine

Two people in a lab

Our cross-faculty multidisciplinary type 1 diabetes clinical research programme is developing technologies to improve the quality of life and reduce the burden of self-management."

Professor Nick Oliver

Head of Section

The section of metabolic medicine undertakes clinical translational research focussing on type 1 diabetes. We co-ordinate the ADDRESS2 study of new-onset type 1 diabetes which is now one of the largest cohorts of adults studied from diagnosis. The ADDRESS2 study has led to new insights into the pathophysiology of type 1 diabetes and work to establish the impact of viruses in the development of type 1 diabetes is ongoing. Active areas of investigation include how both new and existing technologies are applied to type 1 diabetes, with a focus on interventions to prevent hypoglycaemia, and the development and assessment of artificial intelligence strategies to support people living with type 1 diabetes.

We work closely with biomedical engineers to develop new technologies and solutions to support type 1 diabetes self-management including novel glucose sensing modalities, decision support using smartphones, and integration of wearable technologies.

Other research areas include diabetes diagnostic stratification, gestational diabetes and type 2 diabetes prevention, and work to establish key differences between diabetes sub-types across different ethnicities.

Head of Section of Metabolic Medicine

Key studies, research groups and collaborations

  • ADDRESS-2 study - learning about the characteristics of people newly diagnosed with type 1 with diabetes in the UK and supporting other research into type 1 diabetes.
  • ABC4D study - Advanced Bolus Calculator for Diabetes.
  • AIR-CGM - Assessment of the Impact of Real-Time Continuous Glucose Monitoring on People Presenting With Severe Hypoglycaemia.
  • ALPHA - Assessment of the Accuracy of Continuous Glucose Sensors in People With Diabetes Undergoing Haemodialysis.
  • ARISES – Adaptive, Real-time, Intelligent System to Enhance Self-care of chronic disease.
  • BiAP study - Clinical Evaluation of an Artificial Pancreas in people with Type 1 Diabetes. Publication found here.
  • I HART CGM study - Comparison of Continuous Glucose Monitoring vs. Flash Glucose Monitoring in Type 1 diabetes. Publication found here.
  • PACE – The impact of predictive hypoglycaemia alert function in physical activity for people with T1DM.
  • PEPPER study - Personalised Decision Support system for diabetes management in Type 1 Diabetes.
  • MY DIABETES study - Characterising Young-Onset Diabetes in two UK ethnic groups, specifically identifying potential genetic causes to their diabetes known as Maturity Onset Diabetes of the Young (MODY).
  • WynnMet - The Wynn Database: Metabolic Risk Factors and Mortality
Collaborations 
Prof Nick Oliver

Section leadership

Head of Metabolic Medicine 

Nick Oliver is the Wynn Professor of human metabolism and is a consultant in diabetes and endocrinology at Imperial College Healthcare NHS Trust. His clinical and academic interest is type 1 diabetes and the application of technology

Further information on Professor Nick Oliver

Research group leads:

Professor Des Johnston

Professor Des Johnston

Professor Des Johnston
Professor of Clinical Endocrinology

Dr Shivani Misra

Dr Shivani Misra

Dr Shivani Misra
Honorary Clinical Research Fellow

Professor Nick Oliver

Professor Nick Oliver

Professor Nick Oliver
Head of Section of Metabolic Medicine

Dr Monika Reddy

Dr Monika Reddy

Dr Monika Reddy
Honorary Clinical Senior Lecturer