@article{Foster:2026:10.1097/QAD.0000000000004533,
author = {Foster, C and Blenkinsop, A and Henderson, M and Lyall, H and Fidler, S and BONDYstudy, group and BONDYstudy, group},
doi = {10.1097/QAD.0000000000004533},
journal = {AIDS},
title = {Risk factors associated with adverse metabolic health in youth with perinatally acquired HIV living in the United Kingdom.},
url = {http://dx.doi.org/10.1097/QAD.0000000000004533},
year = {2026}
}

Download

TY  - JOUR
AB  - OBJECTIVE: Non-AIDS-related morbidity and mortality in people with HIV are associated with adverse metabolic health, influenced by both traditional- and HIV-related risk factors. There is a paucity of data for youth with perinatal HIV (PHIV). We explored the relationship between markers of metabolic health and antiretroviral therapy (ART) in youth with PHIV. DESIGN: Longitudinal observational cohort study; 26months. METHODS: 85 youth enrolled in the "Bone Density in Youth living with PHIV" (BONDY) underwent assessment of metabolic health including fasting biochemistry, body mass index (BMI), total body dual energy x-ray absorptiometry scan and hepatic transient elastography. RESULTS: Of 85 participants with PHIV, mean age 21.7years, 58% were female and 82% black African. Median ART exposure was 15years, median CD4 count 623cells/μL at enrolment with 82% viral load <200copies/ml. Median weight gain over 26months was 3kg, with BMI category overweight/obese increasing from 37% to 50% with 48% having dyslipidaemia. Metabolic syndrome criteria were fulfilled in 7%, with 13% having hypertension, 18% hepatic steatosis and 7% fibrosis on transient elastography. Bayesian regression analyses demonstrated no association of integrase strand transfer inhibitor (INSTI) and/or tenofovir alafenamide (TAF) use, and sex at birth or prior CDC-C diagnoses or current HIV viraemia on metabolic outcomes. CONCLUSION: While adverse metabolic outcomes are common in this youth cohort with PHIV, no association was observed with INSTI and/or TAF use. Given the relatively young age of this cohort, preventative interventions targeting traditional metabolic risk factors are required to avoid comorbidities in later life.
AU  - Foster,C
AU  - Blenkinsop,A
AU  - Henderson,M
AU  - Lyall,H
AU  - Fidler,S
AU  - BONDYstudy,group
AU  - BONDYstudy,group
DO  - 10.1097/QAD.0000000000004533
PY  - 2026///
TI  - Risk factors associated with adverse metabolic health in youth with perinatally acquired HIV living in the United Kingdom.
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000004533
UR  - https://www.ncbi.nlm.nih.gov/pubmed/42084121
ER  - 

Download