Complement and Inflammation Research

Centre for Complement and Inflammation Research

The Centre for Complement and Inflammation Research (CCIR) aims to understand the molecular and cellular mechanisms of inflammation and the role of the complement system in human disease. Research focuses on how an inflammatory response develops and how this response can contribute to tissue injury, especially in the kidney and skin.

The investigators in the CCIR apply a wide range of cutting-edge techniques including in vivo models, systems-genetics and cellular approaches to understand the molecular and cellular processes underlying renal diseases and autoimmune conditions such as systemic lupus erythematosus (SLE).

The CCIR interfaces with the Imperial Lupus Centre and the Department of Immunology, Imperial College Academic Health Sciences Centre, creating a thriving biomedical environment where fundamental research is linked with clinical diagnostic service.

Research funding sources include the Wellcome Trust, Medical Research Council, Kidney Research UK, Cancer Research UK and the UK Biomedical Research Council.

Head of Centre

Head of Centre for Complement and Inflammation Research
Professor Marina Botto, FMedSci, is the Director of the Centre for Complement and Inflammation Research. She is Professor of Rheumatology, Honorary Consultant Rheumatologist, and the Director of the Bioservices at Imperial College. The focus of her research programme is to understand how the innate immune system, in particular, the complement system, contributes to the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease affecting several organs.

Further information on Professor Botto

Deputy Head

Deputy Head of Centre for Complement and Inflammation Research
Professor Terence Cook's major interest is in elucidating mechanisms of injury in glomerulonephritis.

Further information on Professor Cook