Ongoing Clinical Trials

Mental health top image Drawing on the strength of academic staff working in clinical practice, The Centre for Psychiatry is home to clinical research, including a number of clinical trials of investigative medicinal products and other therapeutic interventions. These trials span a range of the department’s interests including personality disorders, neurodevelopmental disorders, treatment resistant schizophrenia, emotional and behavioural difficulties in early childhood, offender treatment and rehabilitation and behavioural changes following acquired brain injury (ABI).

We have also investigated the prevalence, characteristics, comorbidities and risks in offenders with neurodevelopmental conditions in prison and forensic mental health settings and formed strong collaborations with other universities to participate in clinical and quasi-experimental trials to evaluate treatment outcomes following medical and/or psychological interventions. There is an international collaboration in Denmark with the National Board of Social Services (Socialstyrelsen) and the Danish Prison and Probation Service, involving several municipalities across Denmark, to evaluate outcomes following group and individual psychological treatments for adults with ADHD. Furthermore, it is intended to establish predictors of treatment outcomes using national patient registry data.

Current research projects and their Chief Investigator or Imperial Lead are listed below:

Studies
Study name	Imperial Lead	Description
AFTER	Professor Mike Crawford and Professor Saumitra Deb	A multi-centre, parallel design, randomised, placebo controlled (1:1 ratio) double-blind feasibility trial of risperidone vs. placebo for the treatment of aggression and agitation in patients with traumatic brain injury. Find out more about the trial.
ALITE	Professor Mike Crawford	A feasibility randomised trial of a psychologically informed low-intensity intervention for people with personality disorder.
REMEDY	Professor Mike Crawford	A two-arm, parallel-group, researcher-blind, RCT of enhanced standard care plus switch of antipsychotic drug vs enhanced standard care alone, for people with psychosis who have sexual dysfunction associated with the use of antipsychotic medication.
EULAST	Professor Thomas Barnes	Coordination of the UK participation in the European Long-acting Antipsychotics in Schizophrenia Trial, a large international trial comparing Paliperidone and Aripiprazole in both oral and depot administration.
HSHS	Professor Paul Ramchandani	A feasibility study and pilot trial of a modified video-feedback intervention for children and foster carers to improve mental health outcomes of children in foster care with reactive attachment disorder.
IMAGINATOR	Dr Martina Di Simplicio	A feasibility, proof-of-concept trial of a brief psychological intervention, supported by a smartphone app, for young people who self-harm.


Information correct at time of publishing but subject to change without notice.