If you are interested in taking part we would then contact you by phone for a telephone screening to confirm you are eligible and let you know more about the study. You would then need to come for an initial morning screening visit, followed by 3 study visits over a 4-6 week period. All visits will take place at the NIHR/Wellcome Trust Imperial Clinical Research Facility and the Imanova Centre for Imaging Sciences, at the Hammersmith Hospital (near White City, London W12 0NN).

To be eligible to take part, you need to be:

• Either male or female
• 18-60 years of age

Either

• a cigarette smoker who has recently quit smoking (6 weeks to 2 years ago), or
• a person with alcohol dependence who has recently quit drinking (6 weeks to 5 years ago), or
• overweight or obese, and recently started a weight management programme, and do not have a history of alcohol, tobacco or substance dependence.

Note that even if you have not yet stopped smoking or drinking, or have not yet entered a weight management programme, but are planning to do so in the near future, you can still contact us now to discuss the study. The screening or study visits can then be arranged later at the appropriate time depending on your progress.

• Able to read, speak and understand spoken and written English
• Willing to complete 4 separate visits to the Hammersmith Hospital over approximately 4-6 weeks

You must NOT have had

• a stroke
• a heart attack
• diabetes
• pancreatitis (inflammation of the pancreas)
• a heart pacemaker

You must NOT be

• claustrophobic
• vegetarian, vegan, or gluten- or lactose-intolerant

Please visit the GHADD Study Online Screening Page, so that we can see if you may be eligible to take part. If so, you will be given the opportunity to leave your contact details, so we can discuss the study with you.

Alternatively, if would like to learn more about the study and are happy for us to contact you, please e-mail the study team at ghadd@imperial.ac.uk, or by telephone on 020 7594 6648.