Environmental change poses a major challenge to human health in many parts of the world. The effects of global warming frequently exacerbate the impacts of existing inequality, instability and natural events. Sea level rise, drought, air pollution and ecosystem degradation can lead to significant health impacts, affecting both the incidence of chronic conditions and the spread of infectious disease. Drawing on expertise from across the College and beyond, work focuses on understanding the mechanisms that drive environmental change and tracking their impact on human health. We apply this knowledge to reduce or manage health risks by devising local solutions to help communities adapt to change, but also promoting evidence-based policy development at a regional and national level.