The Challenge

• In 2022, there were more than 600,000 malaria deaths in 85 countries. African countries account for 95% of deaths, 80% of whom were children under five.
•  Progress in tackling malaria has flat-lined, and cases and deaths have been further exacerbated by disruption to health services during the COVID-19 pandemic.
• Existing malaria interventions are becoming less effective as mosquitoes develop biological and behavioural resistance to insecticides and barrier-based controls, while malaria parasites develop resistance to treatment. New tools to tackle malaria are desperately needed.
• Transmission Zero’s gene drive technology offers an environmentally friendly, economically viable, and equitable intervention to curb the spread of malaria, particularly in rural, under-resourced areas.
• Tanzanian expertise and infrastructure provide a high-technology base for further capacity development and regulatory pathfinding in the region.