Group
The group is highly multidisciplinary, with researchers working on synthesis and structural biology, proteomics and cell biology, on in vitro and in vivo systems, often undertaking work in collaboration with labs at Imperial in Medicine, Engineering and Natural Sciences, and groups at institutes and companies across the UK and worldwide. Group membership is also highly diverse - more than 145 researchers have worked in our group over the years, encompassing 28 nationalities.
Staff
Dr Ammar Ahmed
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Dr Ammar Ahmed
Research associate in chemical biology
Dr Edward Bartlett
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Dr Edward Bartlett
Research associate and lab manager (chemical biology)
Daria Berezina
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Daria Berezina
Chemical Biology Technician
Erika Bernardini
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Erika Bernardini
Tissue culture technician
Dr Thomas Burden
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Dr Thomas Burden
MRes Drug Discovery & Development Manager
Dr Fangyuan Cao
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Dr Fangyuan Cao
Pfizer research associate in chemical proteomics
Dr Elena De Vita
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Dr Elena De Vita
Marie Skłodowska-Curie research fellow in medicinal chemistry & covalent drug design (14, 54)
Dr Efthymios Spyridon Gavriil
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Dr Efthymios Spyridon Gavriil
Research associate in medicinal chemistry and cancer drug discovery
Dr Jack Houghton
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Dr Jack Houghton
CRUK research associate in chemical proteomics
Dr Manuel de Jésus Tavares Cornejo
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Dr Manuel de Jésus Tavares Cornejo
Research associate in cancer drug discovery screening
Dr Wouter Kallemeijn
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Dr Wouter Kallemeijn
Senior laboratory research scientist in chemical biology at the Francis Crick Institute
Dr Ana Losada De La Lastra
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Dr Ana Losada De La Lastra
Targeting protein acylation in cancer (50)
Dr Patrycja Michalska Dziama
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Dr Patrycja Michalska Dziama
Marie Curie fellow in chemical biology and novel probe discovery technology
Dr Anne Schuhmacher
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Dr Anne Schuhmacher
SNSF research associate in protein S-acylation
Dr Masha Shchepinova
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Dr Masha Shchepinova
BBSRC research associate in GPCR chemical biology (34-36)
Dr Jemima Thomas
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Dr Jemima Thomas
CRUK Convergence Science Centre research associate in multidisciplinary cancer therapeutics
Dr Josephine Walton
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Dr Josephine Walton
Myricx research scientist, cancer cell biology (60)
PhD students
Roxani Nikoloudaki
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Roxani Nikoloudaki
4th year ICB/Nestlé PhD student, new chemical probes for GPCRs involved in appetite regulation (36)
Miruna Androniciuc
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Miruna Androniciuc
4th year Imperial/Crick PhD, understanding Wnt acylation in development and disease (48)
Qisi Zhang
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Qisi Zhang
4th year ICB CDT PhD, PROTACs for conditional protein degradation
Tom Jackson
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Tom Jackson
4th year ICB CDT PhD, photoswitchable peptide libraries (56, 57)
Jack Williams
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Jack Williams
4th year Crick/Imperial joint PhD, cyclic peptides as chemical probes (56)
Chotima Seripracharat
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Chotima Seripracharat
3rd year PhD, Royal Thai Government, probe synthesis & identifying target of necroptosis inhibitors
James Zhang
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James Zhang
3rd year PhD, CRUK Convergence Centre, NMT as a cancer target (63)
Frederic Buemi
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Frederic Buemi
2nd year PhD student, hydrolytic enzymes driving colorectal cancer development (65)
Shreyas Bhatt
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Shreyas Bhatt
2nd year ICB CDT PhD, Gut-on-a-chip 4.0 (34, 35, 72)
Zuzanna Jablonska
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Zuzanna Jablonska
2nd year PhD student (+ MRes), BHF Centre, new therapeutic targets in ischemic heart disease (66)
Vincent Saverat
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Vincent Saverat
2nd year PhD (+ MRes), ICB and Merck Sharp & Dohme CDT, developing novel biofunctional probes (64)
Matt White
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Matt White
2nd year CRUK/ICB PhD student, chemical proteomics and mechanisms of senescence (73)
Shradda Vadodaria
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Shradda Vadodaria
1st year ICB CDT PhD student, covalent inhibition of a small GTPase
Gaseitsiwe Lame Senatla
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Gaseitsiwe Lame Senatla
1st year PhD student, Botswana Government scholar, inhibitors of hedgehog acyltransferase (62, 69)
Abigail Iles
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Abigail Iles
1st year EPSRC/MSD ICB CDT PhD student, proximity-based drug-target identification (39, 76)
Xinyue Zhang
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Xinyue Zhang
1st year PhD, Imperial-China Scholarship Council, bifunctional discovery platforms
Thomas Maher
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Thomas Maher
1st year PhD (+ MRes) ICB CDT, development of probes investigating G4 interacting proteins (74, 75)
Jack Dainton
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Jack Dainton
1st year ICB CDT MRes + PhD student, high-throughput molecular glue discovery platforms (56)
Anna Kukushkina
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Anna Kukushkina
1st year ICB CDT MRes + PhD student, drugging the intractable interactome (75)
Amy McIntosh
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Amy McIntosh
1st year MRes + PhD student, synthesis of photoactivatable molecular probes (74, 75, 77)
MRes in Drug Discovery and Development students
Khadija Babiker
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Khadija Babiker
Preventing snake venom toxicity (51)
Silvia Vannini
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Silvia Vannini
MOA studies of NMTi in cancer
Other members
Joshua Hope
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Joshua Hope
4th year Crick/Imperial PhD, structural characterisation of the retroviral preintegration complex
Annabel Chatwin
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Annabel Chatwin
MSci student, novel inhibitors of acyl hedgehog transferase (62, 69)
Priantha Pretheshan
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Priantha Pretheshan
MSci student, covalent drugs for GTPase activity (14, 54)
Capucine Solier
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Capucine Solier
Undergraduate student, inhibitors of acyl hedgehog transferase
Robert Gray
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Robert Gray
4th year Crick/Imperial clinical fellow, lipid metabolism in tuberculosis (38)
Alumni
Postdoctoral researchers: 2008: Sasala Wickramasinghe. 2010: Lucia de la Riva Perez. 2011: Dmitry Stetsenko, Vicki Barker, Matt Selby, Ute Brassat. 2012: Will Heal, Victor Goncalves. 2013: Victoria Albrow, Mark Rackham, Zhiyong Yu. 2014: Antonio Konitsiotis, Jennie Hutton. 2015: Goska Broncel, Soo Mei Chee, Kalesh. 2017: Rhiannon Beard, Julia Morales Sanfrutos, Markus Ritzefeld, Inma Perez Dorado. 2018: Remi Serwa, Charlotte Sutherell, Chiara Recchi, Chiara Fabbro. 2019: Aurélien Godinat, Anna Neodo, Scott Lovell, Marc Baggelaar. 2020: Monica Faronato, Tom Lanyon-Hogg. 2021: Ateequllah Hayat, Andrea Goya Grocin, Montse Tersa, Jennie Hutton, Ayesha Tejura (RA), Jasmine Bickel, Andrii Gorelik, Milon Mondal. 2022: Tony Ocasio, Dan Conole, Christelle Soudy, Daniel Lucy, James Sipthorp, Rita Petracca, Ravi Singh. 2023: Sebastian Andrei, Folake Orafidiya.
PhD students: 2009: Panumart Thongyoo. 2010: Gillian Rosenberg. 2011: Jemima Thomas, Tam Dang. 2012: Tayo Olaleye, Lucy Rayner, Alex Berry, Jenny Frueh. 2013: Megan Wright, Manue Thinon. 2014: Chris Douse. 2015: Naoko Masumoto, Paulina Ciepla, Tom Charlton, James Clulow, Andy Bell. 2016: Louis Perdios, Siak Lim, Lisa Storck Saha, Rhiannon Beard, Jenny Ward, Ernie So. 2017: Yunyun Sun, Mostafa Jamshidiha, Greg Craven. 2018: Wenye Zhao, Roman Fedoryshchak, Foteini Tzakoniati, Shao-Ju (Ryan) Lu. 2019: Jessica Shen, Charlie Saunders, Theo Flack, Mladen Stojanovic, Scott Lovell, Eloise Morecroft, Will Joyce, Anja Schlott, Gregor Lueg. 2020: Jasmine Bickel, Kate Hadavizadeh, Nattawadee Panyain, Andrea Goya Grocin, Miha Homsak, Ryan Howard, Cassandra Kennedy. 2022: Leran Zhang, Henry Benns, Simeon Draganov, Emma Couves. 2023: Ana Losada De La Lastra, Cyrille Kounde, Joe Tuersley, Delia Brustur.
MRes students: 2008: Pinar Tulay, Martyna Snopek, Kavita Ramji. 2009: Antoine Delmotte. 2010: Kim Williams, Lucy Esteve, Janet Tsang. 2011: Dani Monteil. 2012: Tiffany Teng, Nino Gaphrindashivili. 2013: Liji Huang, George Bodakh, June Lim, Xiaoyi Wang, Eric Lee. 2014: Yuchen Zhao. 2015: Larissa See, Runzhong Fu, Jason Mak, Sandi Botonjic, Giovanna Morsiani. 2016: Juan Cuadrado, Lerui Guo, Zuzana Hodakova, Miriam Lyons, Niall McLoughlin, Sebastian Soh, Congyi Xu, Handa Zhang. 2017: Rania Al Janabi, Daniel Fernandez Llaneza, Isabella Kaczmarczyk, Sebastian Oehler, Carine Lim, Leran Zhang, Chiara Cecconello. 2018: Irphane Ariff, Sofia Chalkiadaki, Declan Cook, Nicole Deacon-Smith, Sarah Hassan, Kai Hove, Caitlin Jie, Sofia Lachiondo, Bowen Ma, Pasin Mapaisansin, Balazs Pogranyi, Xinzhu Wang. 2019: Billy Baxter, M. Juncal Calvo, Jonathan Davies, Leigh-Anne Gavin, Arzish Haqqee, Thomas Jackson, Callum Johnston, Javier Molina-Bermejo, Jingxing Qiu, Tilly Shackley, Ceire Wincott, Jinwang Yuan. 2020: Debraj Chowdhury, Amrita Date, Lisa Dollhopf, Mathias Fagbemi, Jeff Guo, Ming Huang, Qinxue Kong, Yuxin Liu, Nelli Morgulchik, Nikitas Ostrovitsa, Esther Perez-Barreiro, Panagiota Sarri, Emilia Taylor, Ayesha Tejura, Ioanna Thanasi, Pinqi Wang. 2021: Konstantina Arvaniti, Audrey Dausse, Matthew Dooley, Anusha Gupta, Abigail Iles, Aristo Kong, Caitlin Leo, Xiwen Ma, Amina Nigmatulina, Max Phillips, Jonathan Rockman, Gaseitsiwe Lame Senatla, David Sharp, Shradda Vadodaria, Xinyue Zhang, Peihao Zhao. 2022: Beatrice Bizzotto, Fabiana Ferreira Duarte, Nathan Hardingham, Yaru Meng, Aaron Mothersole, Olivia Ramsay, Haozhe Xiao, Hongyu Ye, Minao Zhang, Kai Zheng.
Undergraduate project/placement students: 2006: Helen Mcleod. 2007: Will Tomlinson, Katherine Elvira, Camille Bonomelli. 2008: James Sudlow. 2009: Irvine Howson, Vlad Turek, Sara Bessin. 2010: Aled Williams, Amanda Cheung, Sascha Yousefi, Genshi Chen. 2011: Machi Panteli, Brian Wilson, Timo Voelker, Wenlin Zhang, Nina Vrielink, Julia Gonzales Hernandes, Sibyl Sheppard. 2012: Enrico Fantoni, Jenny Mizen, Solene Batut, Klaudia Cybulska, Boon Kiat Lee. 2013: Wai Peng Leong, Alice Huynh, Ben Chappell, Sabrina Maas, Chrystalla Constantinou, Will Whitehurst, Saphia Matthew. 2014: Olivia Boyd, James Davies, Xavier Wezen, Shuang Liu, Wouter Mooij, Niall McLoughlin. 2015: Tiffany Chan, Shuang Liu, Markus Artelsmair, Joel Fauser. 2016: Yuen Chow, Michelle Tan, Jenny Samphire, Suk Tan, Annina Burhop, Edward Ou, Alex Bakker, Christine Wu. 2017: Aditya Raymond Thawani, Rhian Hendley, Ana Losada de la Lastra, Dongxun Lyu, Angela Sun. 2019: Stef Bannink, Edward Will, Jianjun (JJ) Ren, Alana Dastous, Camilla Ferro. 2020: Tristan Kovacic, Joshua Newington. 2021: Yongyin (Dorene) Chen, Yicheng Wang. 2022: Fawaz Raja, Anna Kukushkina, Minqi Pan, Ryota Nakao, Haiyang He, Jiaying Zhuang.
Visiting researchers: 2015: Dr Kasia Blewska (Lodz, COST network), Dany Pechalrieu (Toulouse, COST network). 2016: Daniela Glatzova (University of Prague, RSC mobility award). 2018: Wenhua Chen (CSC Scholarship), Elena De Vita (DKFZ, German Cancer Research Center). 2019: Michael Baek (University of Copenhagen). 2020: Jing Han (Institute of Chemistry, Chinese Academy of Sciences), Danai Kati (UCL). 2021: Dr María Maneiro Rey (Xunta de Galicia Fellow). 2022: André Luz (Universidade de Lisboa), Dr Rishi Shah (GSK).
Collaborating labs and organisations
1. Peter O'Hare (Virology); 2. The Francis Crick Institute; 3. Tony Magee (NHLI); 4. Pfizer Neusentis; 5. Medicines for Malaria Venture; 6. Imperial Innovations; 7. Matilda Katan (UCL); 8. Paul French (Laser Physics); 9. Beata Wojciak-Stothard (Medicine); 10. Gad Frankel (Molecular Microbiology); 11. Tony Gee (KCL); 12. Colin Turnbull (Plant Physiology); 13. David Mann (Life Sciences); 14. Ernesto Cota (Structural Biology); 15. Institute of Cancer Research; 16. David Klug (Chemistry); 17. Reiko Tanaka (Bioengineering); 18. Syngenta; 19. Alan Armstrong (Chemistry); 20. Jamie Scott, Jeffrey Johannes (AstraZeneca); 21. Oscar Ces (Chemistry); 22. Jake Baum (Parasitology); 23. Xiaodong Zhang (Structural Biology); 24. Chiara Recchi (Oncology); 25. Keith Willison (Chemistry); 26. Hani Gabra (Oncology); 27. Tony Holder (Crick); 28. Dinis Calado (Crick); 29. Anna Barnard (Chemistry); 30. Doryen Bubeck (Structural Biology); 31. Charlotte Dodson (Biophysics); 32. Edgar Deu (Crick); 33. Alex Lyons (Medicine, NHLI); 34. Gary Frost (Medicine); 35. Aylin Hanyaloglu (Medicine); 36. Nestlé; 37. Susana Godinho (The Barts Cancer Institute, London); 38. Luiz Pedro Carvalho (Crick); 39. Avinash Shenoy (Microbiology); 40. Genentech; 41. John Harling (GSK); 42. Marcel Muelbaier (Cellzome/GSK); 43. Eric Aboagye (Surgery and Cancer); 44. Charlotte Bevan (Surgery and Cancer); 45. Hani Gabra (Surgery and Cancer); 46. Matt Child (Life Sciences); 47. Pete DiMaggio (Chemical Engineering); 48. Jean-Paul Vincent (Crick); 49. Evgen Pharma; 50. Julian Downward (Crick); 51. Vania Braga (Medicine); 52. Heptares; 53. Alan Spivey (Chemistry); 54. Jim Norman (CRUK, Beatson Institute, Glasgow); 55. Hector Keun (Surgery and Cancer); 56. Louise Walport (Crick); 57. Matthew Fuchter (Chemistry); 58. Rui Moreira, Cecília M. P. Rodrigues (Universidade de Lisboa); 59. Iain McNeish (Surgery and Cancer); 60. Myricx Pharma Ltd; 61. Dorian Haskard (Medicine); 62. Christian Siebold (Oxford); 63. Lou Chesler (ICR); 64. Mark Rackham (MSD); 65. Rachael Barry (Medicine); 66. Michela Noseda (Medicine); 67. Ben Perry (DNDi); 68. Andrew Edwards (Medicine); 69. Tom Lanyon-Hogg (Oxford); 70. David Gray (Dundee); 71. Steve Matthews (Structural Biology); 72. Joshua Edel (Chemistry); 73. Jesús Gil (Medicine); 74. Ramón Vilar Compte (Chemistry); 75. Marco Di Antonio (Chemistry); 76. James Bull (Chemistry); 77. David Hewings (Vertex Pharm. Ltd); 78. ADC Therapeutics; 79. Konstantinos Beis (Life Sciences); 80. David Carling (Medicine).