@article{Irrmischer:2026:10.1523/JNEUROSCI.0344-25.2025,
author = {Irrmischer, M and Aqil, M and Luan, L and Wang, T and Engelbregt, H and Carhart-Harris, R and Linkenkaer-Hansen, K and Timmermann, C},
doi = {10.1523/JNEUROSCI.0344-25.2025},
journal = {J Neurosci},
title = {DMT-Induced Shifts in Criticality Correlate with Self-Dissolution.},
url = {http://dx.doi.org/10.1523/JNEUROSCI.0344-25.2025},
volume = {46},
year = {2026}
}

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TY  - JOUR
AB  - Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant for healthy function. Alterations in the proximity to criticality have been suggested to underlie the experiential and neurological effects of psychedelics. Here, we investigate the effects of a psychedelic substance (DMT) on the criticality of brain oscillations, and in relation to subjective experience, in humans of either sex. We find that DMT shifts the dynamics of brain oscillations away from criticality in alpha and adjacent frequency bands. In this context, entropy is increased while complexity is reduced. We find that the criticality-shifts observed in alpha and theta bands correlate with the intensity ratings of self-dissolution, a hallmark of psychedelic experience. Finally, using a recently developed metric, the functional excitatory-inhibitory ratio, we find that the DMT-induced criticality-shift in brain oscillations is toward subcritical regimes. These findings have major implications for the neuronal understanding of the self and psychedelics, as well as for the neurological basis of altered states of consciousness.
AU  - Irrmischer,M
AU  - Aqil,M
AU  - Luan,L
AU  - Wang,T
AU  - Engelbregt,H
AU  - Carhart-Harris,R
AU  - Linkenkaer-Hansen,K
AU  - Timmermann,C
DO  - 10.1523/JNEUROSCI.0344-25.2025
PY  - 2026///
TI  - DMT-Induced Shifts in Criticality Correlate with Self-Dissolution.
T2  - J Neurosci
UR  - http://dx.doi.org/10.1523/JNEUROSCI.0344-25.2025
UR  - https://www.ncbi.nlm.nih.gov/pubmed/41285580
VL  - 46
ER  - 

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