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• Journal article
  Siakalli C, Osborne BE, Brown RK, Rocco C, Weiss D, García-España EV, Grundler PV, Moiseeva AN, Talip Z, van der Meulen NP, Ma MT, Long NJet al., 2026,

  Hydroxyquinoline-functionalised aza-crown macrocycles for lanthanide coordination.

  , Dalton Trans

  Emerging therapeutic radiolanthanides have utility for systemic molecular radiotherapy in nuclear medicine, provided that suitable chemical technology is available to incorporate them into receptor-targeted radiopharmaceuticals. In this work, N,N'-bis(8-hydroxyquinoline-2-ylmethyl)-4,13-diaza-18-crown-6 (H2KHQ) was synthesised, and its binding ability, thermodynamic stability and selectivity for Ln3+ ions (Ln3+ = La, Tb, and Lu) investigated. The design of H2KHQ involves pendant arms featuring 8-hydroxyquinoline units, known to possess metal-chelating properties and desirable activity in other therapeutic molecules. H2KHQ exhibited selectivity for the larger Ln3+ ions, confirmed by experimentally measured stability constants as well as DFT calculations. H2KHQ was able to bind the larger, non-radioactive La3+ and Tb3+ ions within 30 minutes at room temperature, forming a single, 2-fold symmetric species in solution. The structure of [La-HKHQ]2+, as determined by single crystal XRD, emphasized the need for high denticity chelators to satisfy the coordination sphere of the Ln3+, showing a 10-coordinate La3+ metal centre. H2KHQ was radiolabelled with [161Tb]TbCl3 under mild conditions in 92% radiochemical yield in promising proof-of-concept measurements.

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• Journal article
  Zhu Y, Cheng Z, Zhang J, Feng L, Mishra A, de Rosales RTM, Brown RK, Long N, Law G-Let al., 2026,

  Influences of Ring Sizes and Chiral Substituents on Macrocyclic Chelators for Improving 68Ga Radiolabeling.

  , JACS Au, Vol: 6, Pages: 113-123

  68Ga-labeled macrocyclic ligands have been extensively studied and used for positron emission tomography (PET) imaging. Compared with 12-membered DOTA derivatives, NOTA-based chelators with 9-membered macrocyclic rings exhibit more advantageous coordination stability for Ga3+ ions. However, studies of the 10-membered DETA macrocycle are still quite limited. Here, we present the synthesis of four different-sized chiral macrocyclic ligands L1-L4, followed by radiolabeling and stability studies to reveal the influence of ring size and chiral substituents on Ga3+ chelation. In the 68Ga radiolabeling experiments, chiral NOTA L1 exhibits the highest radiochemical yield of 99% at 25 °C. While for the chiral DETA L2/L3 and the chiral DOTA L4, their radiolabeling efficiencies are inferior at room temperature, but remarkable improvements were observed at higher temperatures. L1-L4 all exhibit superior Ga3+ coordination stability than their achiral counterparts, while the chiral DETA L2 with an α-methyl group shows a slightly better performance than its β-analogue L3. Serum stability tests and kinetic studies under acid and alkaline conditions were conducted, highlighting the favorable kinetic inertness of these chiral ligands for potential 68Ga-labeled PET imaging applications.

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• Journal article
  Webb T, Vanin F, Gao D, Zhu L, Tremlett WDJ, Azaden A, Rodgers A, Jacoutot P, White AJP, Islam MS, Long NJ, Zhu Z, Haque SAet al., 2025,

  Metallocenium salts as tunable dopants for enhanced efficiency of perovskite solar cells

  , ENERGY & ENVIRONMENTAL SCIENCE, ISSN: 1754-5692
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• Journal article
  Li B, Gao D, Vanin F, Zhang C, Yu Z, Wang N, Gong J, Li S, Gong J, Qian L, Lin Y-H, Stolterfoht M, Long NJ, Zhu Zet al., 2025,

  Nanoscale soft interaction-engineered perovskite heterojunctions for highly efficient and reproducible solar cells

  , NATURE COMMUNICATIONS, Vol: 16
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• Journal article
  Alajmi A, Alanazi B, Alresheedi K, Alharbi K, Tremlett WDJ, Long NJ, Lambert C, Ismael Aet al., 2025,

  Light-driven molecular switching achieves 6-order magnitude conductance change in OPE dimers

  , NANOSCALE ADVANCES, ISSN: 2516-0230
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• Journal article
  Chen H, Lim Kee Chang W, Mcmullon GT, Yu Y, Woolley BP, Geoghegan G, Yalcin C, Morse SV, Lythgoe MF, Choi JJ, Long NJet al., 2025,

  Tetrazine-<i>trans</i>-cyclooctene ligated lanthanide conjugates for biomedical imaging

  , INORGANIC CHEMISTRY FRONTIERS, ISSN: 2052-1553
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• Journal article
  Patel N, Pham TT, Banu A, Griffiths A, Paterson BM, Firth G, Morrell A, McMahon C, Long NJ, Baker JR, Chudasama V, Ma MTet al., 2025,

  Mass spectrometric imaging and quantitative analysis of the <i>in vivo</i> biodistribution of trastuzumab using a rhodium(<sc>iii</sc>) sarcophagine complex

  , INORGANIC CHEMISTRY FRONTIERS, Vol: 12, ISSN: 2052-1553
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• Conference paper
  Boyle J, Chiappo D, Cooper S, Tapeng L, Sinha S, Walter E, Lai T, Long Net al., 2025,

  Aminocoumarin-based heme oxygenase activity fluorescence probe reveals novel aspects of HO-1 regulation

  , 93rd Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, ISSN: 0021-9150
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• Journal article
  Walter ERH, Lee LC-C, Leung PK-K, Lo KK-W, Long NJet al., 2025,

  Bioorthogonal activation and mitochondrial targeting of a near-infrared-emitting iridium(<sc>iii</sc>) nitrone complex <i>via</i> cyclooctynylated phosphonium cations for enhanced cellular imaging and photodynamic therapy

  , INORGANIC CHEMISTRY FRONTIERS, ISSN: 2052-1553
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  • Citations: 1
• Journal article
  Mann P, Bourke S, Urbano L, Morgan DJ, Dailey LA, Centelles M, Thanou M, Long NJ, Green MAet al., 2025,

  The synthesis and optical properties of Cu-In-S/ZnS nanocrystals in buffer solution for near-infrared fluorescence imaging

  , JOURNAL OF MATERIALS CHEMISTRY B, Vol: 13, Pages: 5871-5879, ISSN: 2050-750X
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• Journal article
  Yeung Y-H, Lam P-L, Thor W, Kai H-Y, Cheung T-L, Wu Y, Law G-L, Long NJ, Wong K-Let al., 2025,

  An Efficient Solid-Phase Synthetic Approach to Prepare TACN-Functionalized Peptides

  , CHEMISTRY-METHODS, Vol: 5, ISSN: 2628-9725
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  • Citations: 1
• Journal article
  Vanin F, Tremlett WDJ, Gao D, Liu Q, Li B, Li S, Gong J, Wu X, Li Z, Brown RK, Qian L, Zhang C, Sun X, Li X, Zeng XC, Zhu Z, Long NJet al., 2025,

  Modulating Perovskite Surface Energetics Through Tuneable Ferrocene Interlayers for High-Performance Perovskite Solar Cells

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 64
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  • Citations: 4
• Journal article
  Koh J, Baker CA, Diamantakis MN, Long NJ, Romain Cet al., 2025,

  A pinch of silver salt to enable <i>rac</i>-lactide ring-opening polymerisation at room temperature using Ti-salen complexes

  , POLYMER CHEMISTRY, Vol: 16, Pages: 1503-1508, ISSN: 1759-9954
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  • Citations: 1
• Journal article
  Hong E, Tremlett WDJ, Hart L, Hu B, Qiao Z, Sukpoonprom P, Fearn S, Angela E, Brunetta M, Koutsogeorgis DC, Kalfagiannis N, Nodari D, Mclachlan MA, Barnes PRF, Bakulin AA, Long NJ, Gasparini Net al., 2025,

  Ferrocene Derivatives Enable Ultrasensitive Perovskite Photodetectors with Enhanced Reverse Bias Stability

  , ADVANCED FUNCTIONAL MATERIALS, ISSN: 1616-301X
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• Journal article
  Woolley B, Wu Y, Xiong L, Chau H-F, Zhang J, Law G-L, Wong K-L, Long NJet al., 2025,

  Lanthanide-tetrazine probes for bio-imaging and click chemistry

  , CHEMICAL SCIENCE, Vol: 16, Pages: 3588-3597, ISSN: 2041-6520
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  • Citations: 1

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