@article{Hull:2026:10.1016/S2213-2600(26)00057-3,
author = {Hull, RC and Liu, Y and Cao, Z and Xuan, KTL and de, Lima Headley DA and Richardson, H and Hennayake, C and Lind, H and McIntosh, E and Pollock, J and Hughes, C and Viligorska, K and Choi, H and Gao, Y and Chotirmall, SH and Shoemark, A and Robertson, K and Burgel, P-R and Vendrell, M and Xu, X and Qu, J-M and Song, Y and Guan, W-J and Chen, R and Singh, S and Talwar, D and Mohan, BVM and Tripathi, SK and Swarnakar, R and Trivedi, S and Goeminne, PC and Shteinberg, M and De, Soyza A and Altenburg, J and Haworth, CS and Sibila, O and Polverino, E and Loebinger, MR and Ringshausen, FC and Mertsch, P and Lorent, N and Dimakou, K and Mendez, R and Mclaughlin, AM and Borrill, Z and Lord, R and Finch, S and Blasi, F and Burr, L and Crisafulli, M and Keating, R and Middleton, PG and Long, MB and Aliberti, S and Morgan, L and Dhar, R and Chalmers, JD and Xu, J-F and EMBARC and EMBARC, India and Australian, bronchiectasis registry and BE-China},
doi = {10.1016/S2213-2600(26)00057-3},
journal = {Lancet Respir Med},
pages = {620--632},
title = {Comorbid diabetes disease severity and microbial changes in patients with bronchiectasis: a combined analysis of data from the EMBARC, EMBARC-India, Australian, and BE-China registries.},
url = {http://dx.doi.org/10.1016/S2213-2600(26)00057-3},
volume = {14},
year = {2026}
}

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TY  - JOUR
AB  - BACKGROUND: Bronchiectasis and diabetes commonly coexist and are associated with immune dysfunction and increased susceptibility to infection. Although diabetes is associated with worse prognosis in cystic fibrosis-related bronchiectasis, data are scarce for its impact on non-cystic fibrosis bronchiectasis. This study aimed to characterise the impact of diabetes on clinical outcomes and microbial and inflammatory profiles in patients with bronchiectasis. METHODS: This analysis comprised data from the European Bronchiectasis Registry (EMBARC), Respiratory Research Network of India (EMBARC-India), Chinese Bronchiectasis Registry (BE-China), and Australian Bronchiectasis Registry (ABR); 30263 patients with CT-confirmed bronchiectasis in 33 countries were included in the analysis: 16963 from EMBARC (Jan 12, 2015, to April 12, 2022), 2361 from EMBARC-India plus additional Asian countries (June 1, 2015, to Sept 1, 2017), 10324 from BE-China (Jan 10, 2020, to March 31, 2024), and 615 from the ABR (March 7, 2016, to Sept 11, 2018). Clinical data were compared between patients with and without diabetes. Long-term outcome data were available in EMBARC and EMBARC-India. Microbiome and inflammatory profiles were characterised in a sub-cohort of EMBARC patients by sputum 16S rRNA sequencing (n=433) and serum Olink (n=479). FINDINGS: 2487 (8·2%) of 30263 patients with bronchiectasis had diabetes. Patients with diabetes had a higher prevalence of comorbidities than those without diabetes, including cardiovascular disorders (53·5% vs 21·8%, p<0·0001), asthma (27·5% vs 21·0%, p<0·0001), and chronic obstructive pulmonary disease (34·3% vs 19·0%, p<0·0001). Patients with diabetes had more severe disease than those without diabetes, with higher Bronchiectasis Severity Index scores (8 [IQR 5-12] vs 7 [4-10], p<0·0001) and UK Medical Research Council (MRC) dyspnoea scores (p<0·0001) and
AU  - Hull,RC
AU  - Liu,Y
AU  - Cao,Z
AU  - Xuan,KTL
AU  - de,Lima Headley DA
AU  - Richardson,H
AU  - Hennayake,C
AU  - Lind,H
AU  - McIntosh,E
AU  - Pollock,J
AU  - Hughes,C
AU  - Viligorska,K
AU  - Choi,H
AU  - Gao,Y
AU  - Chotirmall,SH
AU  - Shoemark,A
AU  - Robertson,K
AU  - Burgel,P-R
AU  - Vendrell,M
AU  - Xu,X
AU  - Qu,J-M
AU  - Song,Y
AU  - Guan,W-J
AU  - Chen,R
AU  - Singh,S
AU  - Talwar,D
AU  - Mohan,BVM
AU  - Tripathi,SK
AU  - Swarnakar,R
AU  - Trivedi,S
AU  - Goeminne,PC
AU  - Shteinberg,M
AU  - De,Soyza A
AU  - Altenburg,J
AU  - Haworth,CS
AU  - Sibila,O
AU  - Polverino,E
AU  - Loebinger,MR
AU  - Ringshausen,FC
AU  - Mertsch,P
AU  - Lorent,N
AU  - Dimakou,K
AU  - Mendez,R
AU  - Mclaughlin,AM
AU  - Borrill,Z
AU  - Lord,R
AU  - Finch,S
AU  - Blasi,F
AU  - Burr,L
AU  - Crisafulli,M
AU  - Keating,R
AU  - Middleton,PG
AU  - Long,MB
AU  - Aliberti,S
AU  - Morgan,L
AU  - Dhar,R
AU  - Chalmers,JD
AU  - Xu,J-F
AU  - EMBARC
AU  - EMBARC,India
AU  - Australian,bronchiectasis registry and BE-China
DO  - 10.1016/S2213-2600(26)00057-3
EP  - 632
PY  - 2026///
SP  - 620
TI  - Comorbid diabetes disease severity and microbial changes in patients with bronchiectasis: a combined analysis of data from the EMBARC, EMBARC-India, Australian, and BE-China registries.
T2  - Lancet Respir Med
UR  - http://dx.doi.org/10.1016/S2213-2600(26)00057-3
UR  - https://www.ncbi.nlm.nih.gov/pubmed/42155496
VL  - 14
ER  - 

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